Evidence map›Paper›PMID 27886205›Full record

ArticleScientific reports2016

A Subset of Malignant Mesothelioma Tumors Retain Osteogenic Potential.

S M Lansley, B Pedersen, C Robinson, R G Searles, G Sterrett, I van Bruggen, R A Lake, S E Mutsaers, C M Prêle

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

S M LansleyInstitute for Respiratory Health and Centre for Respiratory Health, School of Medicine and Pharmacology, University of Western Australia, Harry Perkins Institute of Medical Research, Nedlands, WA, Australia.
B PedersenInstitute for Respiratory Health and Centre for Respiratory Health, School of Medicine and Pharmacology, University of Western Australia, Harry Perkins Institute of Medical Research, Nedlands, WA, Australia.
C RobinsonNational Centre for Asbestos Related Disease, School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia.
R G SearlesInstitute for Respiratory Health and Centre for Respiratory Health, School of Medicine and Pharmacology, University of Western Australia, Harry Perkins Institute of Medical Research, Nedlands, WA, Australia.
G SterrettAnatomical Pathology Research, PathWest Laboratory Medicine WA and School of Pathology, University of Western Australia, Nedlands, WA, Australia.
I van BruggenNational Centre for Asbestos Related Disease, School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia.
R A LakeNational Centre for Asbestos Related Disease, School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia.
S E MutsaersInstitute for Respiratory Health and Centre for Respiratory Health, School of Medicine and Pharmacology, University of Western Australia, Harry Perkins Institute of Medical Research, Nedlands, WA, Australia.
C M PrêleInstitute for Respiratory Health and Centre for Respiratory Health, School of Medicine and Pharmacology, University of Western Australia, Harry Perkins Institute of Medical Research, Nedlands, WA, Australia.
University of Western Australia · AUHarry Perkins Institute of Medical Research · AUPathwest Laboratory Medicine · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant mesothelioma (MM) is an aggressive serosal tumor associated with asbestos exposure. We previously demonstrated that mesothelial cells differentiate into cells of different mesenchymal lineages and hypothesize that osseous tissue observed in a subset of MM patients is due to local differentiation of MM cells. In this study, the capacity of human and mouse MM cells to differentiate into osteoblast-like cells was determined in vitro using a functional model of bone nodule formation and in vivo using an established model of MM. Human and murine MM cell lines cultured in osteogenic medium expressed alkaline phosphatase and formed mineralized bone-like nodules. Several human and mouse MM cell lines also expressed a number of osteoblast phenotype markers, including runt-related transcription factor 2 (RUNX2), osteopontin, osteonectin and bone sialoprotein mRNA and protein. Histological analysis of murine MM tumors identified areas of ossification within the tumor, similar to those observed in human MM biopsies. These data demonstrate the ability of MM to differentiate into another mesenchymal cell type and suggest that MM cells may contribute to the formation of the heterologous elements observed in MM tumors.

Indexed as

OsteogenesisAdultAlkaline PhosphataseAnimalsBiomarkersCell DifferentiationCell Line, TumorCore Binding Factor Alpha 1 SubunitDexamethasoneFemaleHumansIntegrin-Binding SialoproteinLung NeoplasmsMesotheliomaMesothelioma, MalignantMiceAlkaline PhosphataseBiomarkersCore Binding Factor Alpha 1 SubunitDexamethasoneIntegrin-Binding SialoproteinOsteonectin

Identifiers

PMID27886205
PMCPMC5122867
OpenAlexW2552836919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.