Evidence map›Paper›PMID 27886084›Full record

ArticleInternational journal of molecular sciences2016

Intracranial Thrombus Morphology and Composition Undergoes Time-Dependent Changes in Acute Ischemic Stroke: A CT Densitometry Study.

Slaven Pikija, Jozef Magdic, Vladimir Trkulja, Peter Unterkreuter, Johannes Sebastian Mutzenbach, Helmut F Novak, Friedrich Weymayr, Larissa Hauer, Johann Sellner

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  9. Visualizing thrombosis to improve thrombus resolution.Research and practice in thrombosis and haemostasis · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Slaven PikijaDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria. s.pikija@salk.at.
Jozef MagdicDepartment of Neurology, Univerzitetni Klinični Center, 2000 Maribor, Slovenia. jozef_magdic@yahoo.com.
Vladimir TrkuljaDepartment for Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia. vtrkulja@mef.hr.
Peter UnterkreuterDepartment of Neurology, Bezirkskrankenhaus Lienz, 9900 Lienz, Austria. p.unterkreuter@kh-lienz.at.
Johannes Sebastian MutzenbachDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria. j.mutzenbach@salk.at.
Helmut F NovakDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria. h.novak@salk.at.
Friedrich WeymayrDivision of Neuroradiology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria. f.weymayr@salk.at.
Larissa HauerDepartment of Psychiatry, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria. l.hauer@salk.at.
Johann SellnerDepartment of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria. j.sellner@salk.at.
Paracelsus Medical University · ATLiebherr (Austria) · ATUniversity Clinical Centre Maribor · SIUniversity of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of our study was to assess whether cerebral artery clots undergo time-dependent morphological and compositional changes in acute ischemic stroke. We performed a retrospective chart review of patients admitted within 5 h from symptom onset to three European stroke centers and evaluated non-contrast-enhanced CT (NECT) for hyperdense artery signs (HAS) in 2565 scans. The occlusion site, density of HAS expressed in Hounsfield units (HU), area of HAS, and relative density (rHU) (HU clot/HU non-affected artery) were studied and related to time from symptom onset, clinical severity, stroke etiology, and laboratory parameters. A HAS was present in the middle cerebral artery (MCA) in 185 (7.2%) and further explored. The mean time from symptom onset to CT was 100 min (range 17-300). We found a time-dependent loss of density in the occluded M1 segment within the first 5 h (

Indexed as

AdultAgedAged, 80 and overBiomarkersBrain IschemiaFemaleFibrinogenHumansIntracranial ThrombosisMaleMiddle AgedMiddle Cerebral ArteryNeuroimagingRetrospective StudiesSeverity of Illness IndexStrokeBiomarkersFibrinogenacute ischemic strokeatherosclerosisbiomarkerhyperdense artery signintracranial clotneuroimagingvascular disease

Identifiers

PMID27886084
PMCPMC5133953
OpenAlexW2554856733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.