ArticleBrain sciences2016
Cerebellar Intermittent Theta-Burst Stimulation and Motor Control Training in Individuals with Cervical Dystonia.
Article in Brain sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Theta-burst stimulation as a therapeutic tool in neurological pathology: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- The Effect of Cerebellar rTMS on Modulating Motor Dysfunction in Neurological Disorders: a Systematic Review.Cerebellum (London, England) · 2023Pooled it
- Pain's Adverse Impact on Training-Induced Performance and Neuroplasticity: A Systematic Review.Brain imaging and behavior · 2022Pooled it
- Noninvasive brain stimulation combined with exercise in chronic pain: a systematic review and meta-analysis.Expert review of neurotherapeutics · 2020Pooled it
- Cerebellar motor and non-motor contributions to dystonia pathophysiology and treatment.Dystonia (Lausanne, Switzerland) · 2026Article
- Advances in Cerebellar TMS Therapy: An Updated Systematic Review on Multi-Session Interventions.Biomedicines · 2025Review
- Neurorehabilitation in Dystonia Care: Key Questions of Who Benefits, What Modalities, and When to Intervene.Dystonia (Lausanne, Switzerland) · 2025Article
- Research progress in spasmodic torticollis rehabilitation treatment.World journal of clinical cases · 2024Review
- Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation.Nature neuroscience · 2024Article
- Combination of anodal tDCS of the cerebellum with a goal-oriented motor training to treat cervical dystonia: a pilot case series.Frontiers in neurology · 2024Article
- Beyond Pallidal or Subthalamic Deep Brain Stimulation to Treat Dystonia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia.eLife · 2022Article
- Effects of non-invasive brain stimulation in dystonia: a systematic review and meta-analysis.Therapeutic advances in neurological disorders · 2022Article
- Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches.Frontiers in neurology · 2022Review
- Dystonia and Cerebellum: From Bench to Bedside.Life (Basel, Switzerland) · 2021Review
- New modalities and directions for dystonia care.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Cerebellar Deep Brain Stimulation for Acquired Hemidystonia.Movement disorders clinical practice · 2020Article
- Consensus Paper: Experimental Neurostimulation of the Cerebellum.Cerebellum (London, England) · 2019Review
- Increased Finger-Tapping Related Cerebellar Activation in Cervical Dystonia, Enhanced by Transcranial Stimulation: An Indicator of Compensation?Frontiers in neurology · 2019Article
- Abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions in cervical dystonia.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is emerging evidence that cervical dystonia is a neural network disorder with the cerebellum as a key node. The cerebellum may provide a target for neuromodulation as a therapeutic intervention in cervical dystonia.
objectiveThis study aimed to assess effects of intermittent theta-burst stimulation of the cerebellum on dystonia symptoms, quality of life, hand motor dexterity and cortical neurophysiology using transcranial magnetic stimulation.
methodsSixteen participants with cervical dystonia were randomised into real or sham stimulation groups. Cerebellar neuromodulation was combined with motor training for the neck and an implicit learning task. The intervention was delivered over 10 working days. Outcome measures included dystonia severity and pain, quality of life, hand dexterity, and motor-evoked potentials and cortical silent periods recorded from upper trapezius muscles. Assessments were taken at baseline and after 5 and 10 days, with quality of life also measured 4 and 12 weeks later.
resultsIntermittent theta-burst stimulation improved dystonia severity (Day 5, -5.44 points;
conclusionIntermittent theta-burst stimulation of the cerebellum may improve cervical dystonia symptoms, upper limb motor control and quality of life. The mechanism likely involves promoting neuroplasticity in the cerebellum although the neurophysiology remains to be elucidated. Cerebellar neuromodulation may have potential as a novel treatment intervention for cervical dystonia, although larger confirmatory studies are required.
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Registered trials
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