Trial reportNutrients2016
Effects of Two-Year Vitamin B
Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Homocysteine level at the acute stage of ischemic stroke as a biomarker of poststroke depression: A systematic review and meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Pooled it
- The Impact of Nutrition and Intestinal Microbiome on Elderly Depression-A Systematic Review.Nutrients · 2020Pooled it
- Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial.European journal of nutrition · 2023Trial
- Vitamin D and Vitamin BDiseases (Basel, Switzerland) · 2026Review
- Blood Concentrations of Folic Acid and Homocysteine Are Associated with Treatment-Resistant Depression Among Female Depressed Patients.Biomolecules · 2026Article
- Nutritional interventions for late-life depression: evidence, mechanisms, and clinical assessment tools.Frontiers in nutrition · 2026Review
- From Food to Mood: Psychological and Psychiatric Impact of Diet in Bipolar Disorder.Nutrients · 2025Review
- Serum folate and homocysteine as biomarkers for suicide risk in major depressive disorder: insights in males and younger patients.BMC psychiatry · 2025Observational
- The Neurological Sequelae of Vitamin B12 Deficiency: A Systematic Review and Randomized Controlled Trial.Cureus · 2025Review
- Association between homocysteine levels and cognition in late-life depression.Frontiers in psychiatry · 2025Article
- The association of vitamin deficiency with depression risk in late-life depression: a review.Frontiers in nutrition · 2025Review
- Review
- Serum Vitamin Levels, Cardiovascular Disease Risk Factors, and Their Association with Depression in Korean Women: A Cross-Sectional Study of a Nationally Representative Sample.Medicina (Kaunas, Lithuania) · 2023Article
- Partial Response to Antidepressant Treatment: The Role of Nutraceutical Compounds.Clinical neuropsychiatry · 2023Article
- Neurological Implications of Vitamin B12 Deficiency in Diet: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2023Review
- SARS-CoV-2 Infection: What Is Currently Known about Homocysteine Involvement?Diagnostics (Basel, Switzerland) · 2022Review
- Influences of Vitamin BNutrients · 2022Article
- Dietary Supplementations and Depression.Journal of multidisciplinary healthcare · 2022Review
- Healthy diet, depression and quality of life: A narrative review of biological mechanisms and primary prevention opportunities.World journal of psychiatry · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 5 institutions in 2 countries.
Elisa J de KoningEMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. ej.dekoning@vumc.nl.
Nikita L van der ZwaluwDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. nikitavanderzwaluw@gmail.com.
Janneke P van WijngaardenDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. janneke.vanwijngaarden@gmail.com.
Evelien SohlEMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. e.sohl@vumc.nl.
Elske M Brouwer-BrolsmaDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. elkse.brouwer-brolsma@wur.nl.
Harm W J van MarwijkEMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. harm.vanmarwijk@manchester.ac.uk.
Anke W EnnemanDepartment of Internal Medicine, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. a.enneman@erasmusmc.nl.
Karin M A SwartEMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. k.swart@vumc.nl.
Suzanne C van DijkDepartment of Internal Medicine, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. s.c.vandijk@erasmusmc.nl.
Annelies C HamDepartment of Internal Medicine, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. a.ham@erasmusmc.nl.
Nathalie van der VeldeDepartment of Internal Medicine, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. n.vandervelde@erasmusmc.nl.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. a.g.uitterlinden@erasmusmc.nl.
Brenda W J H PenninxEMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. b.penninx@vumc.nl.
Petra J M EldersDepartment of General Practice and Elderly Care Medicine, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. p.elders@vumc.nl.
Paul LipsEMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. p.lips@vumc.nl.
Rosalie A M Dhonukshe-RuttenDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. rosalie-dhonukshe-rutten@wur.nl.
Natasja M van SchoorEMGO Institute for Health and Care Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. nm.vanschoor@vumc.nl.
Lisette C P G M de GrootDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. lisette.degroot@wur.nl.
Amsterdam Public Health · NLErasmus MC · NLWageningen University & Research · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLUniversity of Manchester · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lowering elevated plasma homocysteine (Hcy) concentrations by supplementing vitamin B
Indexed as
AffectDietary SupplementsQuality of LifeAgedAge FactorsBiomarkersDepressionDouble-Blind MethodDrug CombinationsFemaleFolic AcidHomocysteineHumansHyperhomocysteinemiaMaleNetherlandsBiomarkersDrug CombinationsFolic AcidHomocysteineVitamin B 12depressive symptomsfolic acidhomocysteinehyperhomocysteinemiaolder adultsquality of liferandomized controlled trialvitamin B12
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.