Evidence map›Paper›PMID 27886064›Full record

Trial reportNutrients2016

Probiotic Supplements Beneficially Affect Tryptophan-Kynurenine Metabolism and Reduce the Incidence of Upper Respiratory Tract Infections in Trained Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Barbara Strasser, Daniela Geiger, Markus Schauer, Johanna M Gostner, Hannes Gatterer, Martin Burtscher, Dietmar Fuchs

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04530929 (Analysis of the Impact of Used Probiotic Strains and Diet on Body Composition, Cardiopulmonary Efficiency and the Incidence of Gastrointestinal Disorders in Runners), which is not on this map. Cited by 71 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 10 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04530929 nacompletednot on this mapstarted 2018, after this paper: background citation

Analysis of the Impact of Used Probiotic Strains and Diet on Body Composition, Cardiopulmonary Efficiency and the Incidence of Gastrointestinal Disorders in Runners

TypeinterventionalSponsorMedical University of BialystokRan2018 to 2018Enrolled66ConditionsGastrointestinal Disorder, FunctionalArmsSANPROBI BARRIER, PLACEBO
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 10 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta-Analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  5. Effects of Probiotics Supplementation on Risk and Severity of Infections in Athletes: A Systematic Review.International journal of environmental research and public health · 2022
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  9. Impact of Probiotics on the Performance of Endurance Athletes: A Systematic Review.International journal of environmental research and public health · 2021
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Barbara StrasserDivision of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria. Barbara.Strasser@i-med.ac.at.
Daniela GeigerDivision of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria. M.Sc.DanielaGeiger@gmail.com.
Markus SchauerDivision of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria. M.Schauer@hotmail.com.
Johanna M GostnerDivision of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria. Johanna.Gostner@i-med.ac.at.
Hannes GattererDepartment of Sport Science, Medical Section, University of Innsbruck, Fuerstenweg 189, 6020 Innsbruck, Austria. Hannes.Gatterer@uibk.ac.at.
Martin BurtscherDepartment of Sport Science, Medical Section, University of Innsbruck, Fuerstenweg 189, 6020 Innsbruck, Austria. Martin.Burtscher@uibk.ac.at.
Dietmar FuchsDivision of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innrain 80, 6020 Innsbruck, Austria. Dietmar.Fuchs@i-med.ac.at.
Innsbruck Medical University · ATUniversität Innsbruck · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProlonged intense exercise has been associated with transient suppression of immune function and an increased risk of infections. In this context, the catabolism of amino acid tryptophan via kynurenine may play an important role. The present study examined the effect of a probiotic supplement on the incidence of upper respiratory tract infections (URTI) and the metabolism of aromatic amino acids after exhaustive aerobic exercise in trained athletes during three months of winter training.

methodsThirty-three highly trained individuals were randomly assigned to probiotic (PRO,

resultsAfter 12 weeks of treatment, post-exercise tryptophan levels were lowered by 11% (a significant change) in the PLA group compared to the concentrations measured before the intervention (

conclusionData indicate reduced exercise-induced tryptophan degradation rates in the PRO group. Daily supplementation with probiotics limited exercise-induced drops in tryptophan levels and reduced the incidence of URTI, however, did not benefit athletic performance.

Indexed as

AthletesAdultAustriaBiomarkersDouble-Blind MethodFemaleGastrointestinal MicrobiomeHealth StatusHumansKynurenineMaleNeopterinPhenylalaninePhysical Conditioning, HumanPhysical EndurancePhysical FitnessBiomarkersKynurenineNeopterinPhenylalanineTryptophanTyrosineintense exercisekynurenineprobioticstryptophanupper respiratory tract infections

Identifiers

PMID27886064
PMCPMC5133134
OpenAlexW2552273282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.