Evidence map›Paper›PMID 27885354›Full record

ArticleMetabolomics : open access2015

A Potential Biofilm Metabolite Signature for Caries Activity - A Pilot Clinical Study.

F Zandona, H A Soini, M V Novotny, E Santiago, G J Eckert, J S Preisser, H K Benecha, R A Arthur, D T Zero

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolomics : open access, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Metabolomics Insights in Early Childhood Caries.Journal of dental research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

F ZandonaDepartment of Operative Dentistry, University of North Carolina School of Dentistry at Chapel Hill, Chapel Hill, USA.
H A SoiniDepartment of Chemistry, Institute for Pheromone Research, Indiana University, Bloomington, Indiana, USA.
M V NovotnyDepartment of Chemistry, Institute for Pheromone Research, Indiana University, Bloomington, Indiana, USA.
E SantiagoSchool of Dentistry Research Center, University of Puerto Rico, San Juan, Puerto Rico, USA.
G J EckertDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
J S PreisserDepartment of Biostatistics, UNC Gillings School of Global Public Health, Chapel Hill, USA.
H K BenechaDepartment of Preventive and Community Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
R A ArthurDepartment of Preventive and Community Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
D T ZeroDepartment of Preventive and Community Dentistry, Indiana University School of Dentistry, Indianapolis, Indiana, USA.
Indiana University Bloomington · US

Funding

INDIANA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UL1): BPCAUL1RR025761 · NCRR · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2008 to 2011
$21.0M
Clinical Validation of Combined ICDAS/QLF Exam for Early Caries DetectionR01DE017890 · NIDCR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI ZANDONA, ANDREA GONCALVES FERREIRA · 2006 to 2010
$3.3M
Clinical Validation of a Biofilm Signature for Early Caries Activity AssessmentR56DE017890 · NIDCR · INDIANA UNIVERSITY INDIANAPOLIS · PI ZANDONA, ANDREA GONCALVES FERREIRA · 2012 to 2012
$139k
NCRR NIH HHS UL1 RR025761NIDCR NIH HHS R01 DE017890NIDCR NIH HHS R56 DE017890
6 · The paper itself

Abstract

backgroundThis study's aim was to compare the dental biofilm metabolite-profile of caries-active (N=11) or caries-free (N=4) children by gas chromatography-mass spectrometry (GC/MS) analyses.

methodsSamples collected after overnight fasting, with or without a previous glucose rinse, were combined for each child based on the caries status of the site, re-suspended in ethanol and analyzed by GC/MS.

resultsBiofilm from caries-active sites exhibited a different chromatographic profile compared to caries-free sites. Qualitative and quantitative analysis suggested a special cluster of branched alcohols and esters present at substantially higher intensity in biofilms of caries-active sites.

conclusionsThis pilot study indicates that there are metabolites present in the biofilm which have the potential to provide a characteristic metabolomics signature for caries activity.

Indexed as

BiomarkerCaries-activityDental-cariesGas chromatography-mass spectrometryMetabolites

Identifiers

PMID27885354
PMCPMC5119531
OpenAlexW2317074529

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.