ArticleThorax2017
Mortality from respiratory diseases associated with opium use: a population-based cohort study.
Article in Thorax, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of opium use and use disorder in the Iranian population: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- Prevalence of tobacco use among cancer patients in Iran: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Reinke's Edema and Risk Factors, A Case-Control Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- The effects of opium consumption on severity of disease on hospitalized COVID-19 patients in East of Iran, a prospective cohort study.Translational and clinical pharmacology · 2024Article
- Improvement of esophageal cancer survival in Northeast Iran: A two-decade journey in a high-risk, low- resource region.PloS one · 2024Article
- Prevalence and determinants of opioid use disorder among long-term opiate users in Golestan Cohort Study.BMC psychiatry · 2023Article
- Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence.Open biology · 2023Review
- Epidemiological Study of Lung Cancer in Iran: A Systematic Review.Iranian journal of public health · 2022Review
- Is opium use associated with an increased risk of lung cancer? A case-control study.BMC cancer · 2020Observational
- Opium use and subsequent incidence of cancer: results from the Golestan Cohort Study.The Lancet. Global health · 2020Article
- Individual and Combined Effects of Environmental Risk Factors for Esophageal Cancer Based on Results From the Golestan Cohort Study.Gastroenterology · 2019Article
- Article
- Cancer incidence in the East Azerbaijan province of Iran in 2015-2016: results of a population-based cancer registry.BMC public health · 2018Article
- Prospective Epidemiological Research Studies in Iran (the PERSIAN Cohort Study): Rationale, Objectives, and Design.American journal of epidemiology · 2018Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
backgroundRecent studies have suggested that opium use may increase mortality from cancer and cardiovascular diseases. However, no comprehensive study of opium use and mortality from respiratory diseases has been published. We aimed to study the association between opium use and mortality from respiratory disease using prospectively collected data.
methodsWe used data from the Golestan Cohort Study, a prospective cohort study in northeastern Iran, with detailed, validated data on opium use and several other exposures. A total of 50 045 adults were enrolled from 2004 to 2008, and followed annually until June 2015, with a follow-up success rate of 99%. We used Cox proportional hazard regression models to evaluate the association between opium use and outcomes of interest.
resultsDuring the follow-up period, 331 deaths from respiratory disease were reported (85 due to respiratory malignancies and 246 due to non-malignant aetiologies). Opium use was associated with an increased risk of death from any respiratory disease (adjusted HR 95% CI 3.13 (2.42 to 4.04)). The association was dose-dependent with a HR of 3.84 (2.61 to 5.67) for the highest quintile of cumulative opium use versus never use (P
conclusionsLong-term opium use is associated with increased mortality from both malignant and non-malignant respiratory diseases.
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