ReviewScience (New York, N.Y.)2016
Circadian physiology of metabolism.
Review in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 624 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Meal Timing on Neurovascular Control in Adults
Impact of Time-Restricted Eating on Metabolic and Neuroendocrine Homeostasis, Inflammation and Oxidative Stress in Patients With Metabolic Syndrome: the TREMNIOS Pilot Clinical Trial
The Effect of Intermittent Fasting on Immune System
Six Weeks of Time-restricted Feeding Improves Basal Fat Oxidation and Body Composition But Not Fat Oxidation During Exercise in Young Males: A Randomized Controlled Trial
Who cites it
624 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Rehabilitation of Frozen Shoulder: A Systematic Review and Meta-Analysis of Multifactorial Interventions.Pain research & management · 2026Pooled it
- Efficiency of time-restricted eating and energy restriction on anthropometrics and body composition in adults: a systematic review and meta-analysis of randomized controlled trials.The international journal of behavioral nutrition and physical activity · 2025Pooled it
- Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials.BMJ (Clinical research ed.) · 2025Pooled it
- Pooled it
- Relationships between rest-activity rhythms, cancer-related fatigue, and quality of life: Results from a time-restricted eating randomized controlled trial.Chronobiology international · 2026Trial
- The impact of the time of day on muscle and metabolic responses to resistance exercise in healthy adults: A randomised controlled trial.Experimental physiology · 2026Trial
- Time-Restricted Eating Without Exercise Enhances Anaerobic Power and Reduces Body Weight: A Randomized Crossover Trial in Untrained Adults.Nutrients · 2025Trial
- Later eating timing in relation to an individual internal clock is associated with lower insulin sensitivity and affected by genetic factors.EBioMedicine · 2025Trial
- Early Time-Restricted Eating Improves Weight Loss While Preserving Muscle: An 8-Week Trial in Young Women.Nutrients · 2025Trial
- The efficacy of DASH combined with time-restricted feeding (16/8) on metabolic associated fatty liver disease management: a randomized controlled trial.Scientific reports · 2025Trial
- The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial.Scientific reports · 2025Trial
- Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women.Nutrients · 2025Trial
- Glycaemic Response to Acute Aerobic and Anaerobic Exercise Performed in the Morning or Afternoon in Healthy Subjects: A Crossover Trial.Journal of the International Society of Sports Nutrition · 2024Trial
- Circadian synchronization between diet and gut microbiota in modulating host's health.Gut microbes · 2026Review
- Neuroendocrine regulation of appetite and energy balance in metabolic disorders.IBRO neuroscience reports · 2026Review
- Article
- A population of dopaminergic neurons in the substantia nigra is required for food-anticipatory activity.Current biology : CB · 2026Article
- Circadian regulation of hepatic detoxification: implications for drug-induced liver injury.Archives of toxicology · 2026Review
- Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.Life metabolism · 2026Review
- Understanding Postpartum Mothers' Perspectives of Chrononutrition Approaches: A Qualitative Study.Journal of the Academy of Nutrition and Dietetics · 2026Article
564 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
A majority of mammalian genes exhibit daily fluctuations in expression levels, making circadian expression rhythms the largest known regulatory network in normal physiology. Cell-autonomous circadian clocks interact with daily light-dark and feeding-fasting cycles to generate approximately 24-hour oscillations in the function of thousands of genes. Circadian expression of secreted molecules and signaling components transmits timing information between cells and tissues. Such intra- and intercellular daily rhythms optimize physiology both by managing energy use and by temporally segregating incompatible processes. Experimental animal models and epidemiological data indicate that chronic circadian rhythm disruption increases the risk of metabolic diseases. Conversely, time-restricted feeding, which imposes daily cycles of feeding and fasting without caloric reduction, sustains robust diurnal rhythms and can alleviate metabolic diseases. These findings highlight an integrative role of circadian rhythms in physiology and offer a new perspective for treating chronic diseases in which metabolic disruption is a hallmark.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.