Evidence map›Paper›PMID 27884957›Full record

ArticlePhysiological reports2016

Altered CO2 sensitivity of connexin26 mutant hemichannels in vitro.

Elizabeth de Wolf, Joseph van de Wiel, Jonathan Cook, Nicholas Dale

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. COeLife · 2026
    Article
  2. Connexin50 hemichannels are opened by COFrontiers in physiology · 2026
    Article
  3. X-linked Charcot Marie Tooth mutations alter COFrontiers in cellular neuroscience · 2023
    Article
  4. Conformational changes and COStructure (London, England : 1993) · 2022
    Article
  5. Article
  6. COInternational journal of molecular sciences · 2021
    Review
  7. COInterface focus · 2021
    Review
  8. Review
  9. Article
  10. Structural determinants of COCommunications biology · 2019
    Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elizabeth de WolfSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.
Joseph van de WielSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.
Jonathan CookSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.
Nicholas DaleSchool of Life Sciences, University of Warwick, Coventry, United Kingdom N.E.Dale@warwick.ac.uk.
University of Warwick · GB

Funding

Medical Research Council G1001259Medical Research Council MR/N003918/1
6 · The paper itself

Abstract

Connexin26 (Cx26) mutations underlie human pathologies ranging from hearing loss to keratitis ichthyosis deafness (KID) syndrome. Cx26 hemichannels are directly gated by CO

Indexed as

MutationCarbon DioxideConnexin 26ConnexinsDeafnessHearing LossHeLa CellsHumansIchthyosisIntercellular JunctionsKeratitisRespiratory Physiological PhenomenaCarbon DioxideConnexin 26ConnexinsConnexinhemichannelnon‐syndromic hearing lossrespiratory chemosensitivitysyndromic hearing loss

Identifiers

PMID27884957
PMCPMC5357999
OpenAlexW2546542930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.