Evidence map›Paper›PMID 27884761›Full record

ArticleAppetite2017

Assessment of the motivation to use artificial sweetener among individuals with an eating disorder.

Janet Schebendach, Diane A Klein, Laurel E S Mayer, Evelyn Attia, Michael J Devlin, Richard W Foltin, B Timothy Walsh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Appetite, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Cognitive Neuroscience of Eating Disorders.The Psychiatric clinics of North America · 2019
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Janet SchebendachEating Disorders Research Unit, New York State Psychiatric Institute, USA; New York State Psychiatric Institute, 1051 Riverside Drive, Unit 98, New York, NY 10032, USA; Columbia University Medical Center, New York, NY 10032, USA. Electronic address: js2202@cumc.columbia.edu.
Diane A KleinNew York University, Langone Medical Center, Department of Psychiatry, USA.
Laurel E S MayerEating Disorders Research Unit, New York State Psychiatric Institute, USA; New York State Psychiatric Institute, 1051 Riverside Drive, Unit 98, New York, NY 10032, USA; Columbia University Medical Center, New York, NY 10032, USA.
Evelyn AttiaEating Disorders Research Unit, New York State Psychiatric Institute, USA; New York State Psychiatric Institute, 1051 Riverside Drive, Unit 98, New York, NY 10032, USA; Columbia University Medical Center, New York, NY 10032, USA.
Michael J DevlinEating Disorders Research Unit, New York State Psychiatric Institute, USA; New York State Psychiatric Institute, 1051 Riverside Drive, Unit 98, New York, NY 10032, USA; Columbia University Medical Center, New York, NY 10032, USA.
Richard W FoltinDivision on Substance Abuse, New York State Psychiatric Institute, USA; New York State Psychiatric Institute, 1051 Riverside Drive, Unit 98, New York, NY 10032, USA; Columbia University Medical Center, New York, NY 10032, USA.
B Timothy WalshEating Disorders Research Unit, New York State Psychiatric Institute, USA; New York State Psychiatric Institute, 1051 Riverside Drive, Unit 98, New York, NY 10032, USA; Columbia University Medical Center, New York, NY 10032, USA.
Columbia University Irving Medical Center · USNew York Psychoanalytic Society and Institute · USNew York State Office of Alcoholism and Substance Abuse Services · USNew York State Psychiatric InstituteNYU Langone Health · US

Funding

Translational Research on Eating Disorders: Reward SystemsR01MH079397 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI WALSH, B. TIMOTHY · 2008 to 2012
$2.8M
Translational Research on Eating DisordersR21MH065024 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI WALSH, B. TIMOTHY · 2002 to 2006
$2.6M
Excitatory Controls of Eating in Eating DisordersK23MH071285 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KLEIN, DIANE A · 2005 to 2009
$881k
NIMH NIH HHS K23 MH071285NIMH NIH HHS R01 MH079397NIMH NIH HHS R21 MH065024
6 · The paper itself

Abstract

Eating disorders are associated with a range of abnormalities in eating behavior. Some individuals consume large amounts of non-caloric artificial sweeteners, suggesting abnormalities in appetitive responding. The current study aimed to quantify hedonic and motivating effects of artificial sweetener in individuals with and without an eating disorder. Two laboratory studies were conducted. Hedonic preference was estimated using the number of artificial sweetener packets (0-10) added to unsweetened cherry flavored Kool-Aid (study 1). Motivation to obtain sweetener was assessed by a progressive ratio (PR) work task (study 2). Ninety-three participants (25 anorexia nervosa restricting type (AN-R), 23 AN binge/purge type (AN-B/P), 20 bulimia nervosa (BN), and 25 normal controls (NC)) completed the study. No significant difference in hedonic preference was found among participant groups. Work completed at the PR task ranged from 0 to 9500 key-board presses. The AN-B/P group had a significantly higher breakpoint and performed significantly more work for sweetener compared to the BN and NC groups. Among AN-B/P and AN-R participants, the preferred number of Equal packets was significantly correlated with the breakpoint and total work. The increased amount of work for sweetener among individuals with AN-B/P supports an enhanced reward value of sweet taste in this population, and suggests that the characteristic food avoidance in AN cannot be accounted for by decreased reward value of all taste-related stimuli. This study also supports the novel application of a PR ratio task to quantify the motivating effect of sweet taste among individuals with an eating disorder.

Indexed as

MotivationSweetening AgentsAdolescentAdultCase-Control StudiesFeeding and Eating DisordersFeeding BehaviorFemaleFood PreferencesHumansMaleMiddle AgedYoung AdultSweetening AgentsAnorexia nervosaArtificial sweetenerBulimia nervosaEating disordersHedonicsIngestive behaviorMotivationProgressive ratio taskReward

Identifiers

PMID27884761
PMCPMC5201128
OpenAlexW2551541735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.