Evidence map›Paper›PMID 27884746›Full record

ReviewDrug discovery today2017

Collaborative drug discovery for More Medicines for Tuberculosis (MM4TB).

Sean Ekins, Anna Coulon Spektor, Alex M Clark, Krishna Dole, Barry A Bunin

Abstract readReview
In one paragraph

Review in Drug discovery today, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. NTD Health: an electronic medical record system for neglected tropical diseasesBiomedica : revista del Instituto Nacional de Salud · 2022
    Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sean EkinsCollaborative Drug Discovery, Inc., 1633 Bayshore Highway, Suite 342, Burlingame, CA 94010, USA; Collaborations in Chemistry, Inc., 5616 Hilltop Needmore Road, Fuquay-Varina, NC 27526, USA. Electronic address: ekinssean@yahoo.com.
Anna Coulon SpektorCollaborative Drug Discovery, Inc., 1633 Bayshore Highway, Suite 342, Burlingame, CA 94010, USA.
Alex M ClarkCollaborative Drug Discovery, Inc., 1633 Bayshore Highway, Suite 342, Burlingame, CA 94010, USA; Molecular Materials Informatics, Inc., 1900 St. Jacques #302, Montreal H3J 2S1, Quebec, Canada.
Krishna DoleCollaborative Drug Discovery, Inc., 1633 Bayshore Highway, Suite 342, Burlingame, CA 94010, USA.
Barry A BuninCollaborative Drug Discovery, Inc., 1633 Bayshore Highway, Suite 342, Burlingame, CA 94010, USA.

Funding

Biocomputation across distributed private datasets to enhance drug discoveryR44TR000942 · NCATS · COLLABORATIVE DRUG DISCOVERY, INC. · PI BUNIN, BARRY A · 2013 to 2018
$2.9M
Identification of novel therapeutics for tuberculosis combining cheminformatics,R42AI088893 · NIAID · COLLABORATIVE DRUG DISCOVERY, INC. · PI EKINS, SEAN · 2012 to 2013
$997k
NCATS NIH HHS R44 TR000942NIAID NIH HHS R42 AI088893
6 · The paper itself

Abstract

Neglected disease drug discovery is generally poorly funded compared with major diseases and hence there is an increasing focus on collaboration and precompetitive efforts such as public-private partnerships (PPPs). The More Medicines for Tuberculosis (MM4TB) project is one such collaboration funded by the EU with the goal of discovering new drugs for tuberculosis. Collaborative Drug Discovery has provided a commercial web-based platform called CDD Vault which is a hosted collaborative solution for securely sharing diverse chemistry and biology data. Using CDD Vault alongside other commercial and free cheminformatics tools has enabled support of this and other large collaborative projects, aiding drug discovery efforts and fostering collaboration. We will describe CDD's efforts in assisting with the MM4TB project.

Indexed as

Antitubercular AgentsDrug DiscoveryAnimalsHumansMachine LearningMolecular Targeted TherapyTuberculosisAntitubercular Agents

Identifiers

PMID27884746
PMCPMC5362323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.