Evidence map›Paper›PMID 27883901›Full record

ReviewNeuron2016

Tapping the Brakes: Cellular and Synaptic Mechanisms that Regulate Thalamic Oscillations.

P Michelle Fogerson, John R Huguenard

Abstract readReview
In one paragraph

Review in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Trial
  2. Article
  3. Lipid Activation of a Thalamic GPCR Extends Working Memory Time-scales.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. KArchiv der Pharmazie · 2026
    Review
  8. Article
  9. Article
  10. Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026
    Review
  11. Review
  12. Article
  13. Generalized Slowing of Resting-State Neural Oscillations in People With Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Causal Cortical and Thalamic Connections in the Human Brain.bioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Modulators of GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

P Michelle FogersonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
John R HuguenardDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: john.huguenard@stanford.edu.

Funding

Inhibitory Controls of Thalamic NeuronsR01NS034774 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 1996 to 2021
$5.5M
EPILEPSY TRAINING PROGRAMT32NS007280 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 1985 to 2020
$3.6M
Inhibitory Controls in the Thalamic Reticular NucleusR37NS034774 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 2004 to 2010
$2.5M
Astrocytic Control of GABA Inhibition in EpilepsyR01NS090911 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 2014 to 2017
$1.5M
Solid-state patch clamp platform to diagnose autism and screen for effective drugR33MH100717 · NIMH · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 2016 to 2017
$778k
NIMH NIH HHS R33 MH100717NINDS NIH HHS R01 NS034774NINDS NIH HHS R01 NS090911NINDS NIH HHS R37 NS034774NINDS NIH HHS T32 NS007280
6 · The paper itself

Abstract

Thalamic oscillators contribute to both normal rhythms associated with sleep and anesthesia and abnormal, hypersynchronous oscillations that manifest behaviorally as absence seizures. In this review, we highlight new findings that refine thalamic contributions to cortical rhythms and suggest that thalamic oscillators may be subject to both local and global control. We describe endogenous thalamic mechanisms that limit network synchrony and discuss how these protective brakes might be restored to prevent absence seizures. Finally, we describe how intrinsic and circuit-level specializations among thalamocortical loops may determine their involvement in widespread oscillations and render subsets of thalamic nuclei especially vulnerable to pathological synchrony.

Indexed as

Brain WavesCerebral CortexEpilepsyHumansNeuronsSleepThalamic NucleiThalamusabsence epilepsyoscillationreticular nucleussparse networksspindlesynchronythalamus

Identifiers

PMID27883901
PMCPMC5131525

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.