Evidence map›Paper›PMID 27883199›Full record

ArticleAmerican journal of hematology2017

Hepcidin detects iron deficiency in Sri Lankan adolescents with a high burden of hemoglobinopathy: A diagnostic test accuracy study.

Katherine Wray, Angela Allen, Emma Evans, Chris Fisher, Anuja Premawardhena, Lakshman Perera, Rexan Rodrigo, Gayan Goonathilaka, Lebbe Ramees, Craig Webster and 5 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Katherine WrayMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Angela AllenLiverpool School of Tropical Medicine, Centre for Tropical and Infectious Diseases, Liverpool, UK.
Emma EvansDepartment of Biochemistry and Immunology, Birmingham Heartlands Hospital, Birmingham, UK.
Chris FisherMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Anuja PremawardhenaDepartment of Medicine, University of Kelaniya, Colombo, Sri Lanka.
Lakshman PereraDepartment of Medicine, University of Kelaniya, Colombo, Sri Lanka.
Rexan RodrigoDepartment of Medicine, University of Kelaniya, Colombo, Sri Lanka.
Gayan GoonathilakaDepartment of Medicine, University of Kelaniya, Colombo, Sri Lanka.
Lebbe RameesDepartment of Medicine, University of Kelaniya, Colombo, Sri Lanka.
Craig WebsterDepartment of Biochemistry and Immunology, Birmingham Heartlands Hospital, Birmingham, UK.
Andrew E ArmitageMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Andrew M PrenticeMRC Unit The Gambia, MRC Keneba, The Gambia.
David J WeatherallMRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Hal DrakesmithMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Sant-Rayn PasrichaMRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
University of Kelaniya · LKHeartlands Hospital · GBMRC Human Immunology Unit · GBMRC Weatherall Institute of Molecular Medicine · GBLiverpool School of Tropical Medicine · GBOxford BioMedica (United Kingdom) · GBUniversity of London · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_U123292699Medical Research Council MC_UU_00016/12Medical Research Council MC_UU_12009/13Medical Research Council MC_UU_12010/10
6 · The paper itself

Abstract

Anemia affects over 800 million women and children globally. Measurement of hepcidin as an index of iron status shows promise, but its diagnostic performance where hemoglobinopathies are prevalent is unclear. We evaluated the performance of hepcidin as a diagnostic test of iron deficiency in adolescents across Sri Lanka. We selected 2273 samples from a nationally representative cross-sectional study of 7526 secondary schoolchildren across Sri Lanka and analyzed associations between hepcidin and participant characteristics, iron indices, inflammatory markers, and hemoglobinopathy states. We evaluated the diagnostic accuracy of hepcidin as a test for iron deficiency with estimation of the AUC

Indexed as

AdolescentAnemia, Iron-DeficiencyChildCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHemoglobinopathiesHemoglobinsHepcidinsHumansMaleSensitivity and SpecificitySri LankaYoung AdultHemoglobinsHepcidins

Identifiers

PMID27883199
PMCPMC5324588
OpenAlexW2559245710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.