Evidence map›Paper›PMID 27883084›Full record

ArticleScientific reports2016

Nucleoside-Diphosphate-Kinase of P. gingivalis is Secreted from Epithelial Cells In the Absence of a Leader Sequence Through a Pannexin-1 Interactome.

Kalina Atanasova, Jungnam Lee, JoAnn Roberts, Kyulim Lee, David M Ojcius, Özlem Yilmaz

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. Opportunistic pathogeniScience · 2024
    Article
  2. Article
  3. Review
  4. Article
  5. Regulatory effects of oral microbe on intestinal microbiota and the illness.Frontiers in cellular and infection microbiology · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Inflammasome Activation in Gingival Epithelial Cells.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  10. Review
  11. P2RX7 at the Host-Pathogen Interface of Infectious Diseases.Microbiology and molecular biology reviews : MMBR · 2021
    Review
  12. Article
  13. Current research in microbial sciences · 2020
    Article
  14. Article
  15. Immunological Pathways Triggered byMediators of inflammation · 2019
    Review
  16. Possible role ofJournal of oral microbiology · 2019
    Review
  17. Article
  18. Article
  19. The 'known-knowns', and 'known-unknowns' of extracellular Nm23-H1/NDPK proteins.Laboratory investigation; a journal of technical methods and pathology · 2018
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kalina AtanasovaDepartment of Periodontology, University of Florida, Gainesville, Florida, USA.
Jungnam LeeDepartment of Periodontology, University of Florida, Gainesville, Florida, USA.
JoAnn RobertsDepartment of Oral Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Kyulim LeeDepartment of Periodontology, University of Florida, Gainesville, Florida, USA.
David M OjciusDepartment of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, USA.
Özlem YilmazDepartment of Oral Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
University of Florida · USMedical University of South Carolina · USUniversity of the Pacific · US

Funding

T-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3M
Comprehensive Training Program in Oral BiologyT90DE021990 · NIDCR · UNIVERSITY OF FLORIDA · PI Jose A Lemos · 2011 to 2026
$8.2M
Pilot and Feasibility Project ProgramP30GM103331 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KIRKWOOD, KEITH L · 2012 to 2016
$5.2M
Role of the Spx Regulator in Streptococcus mutansR01DE019783 · NIDCR · UNIVERSITY OF ROCHESTER · PI LEMOS, JOSE A · 2010 to 2020
$3.7M
Modulation of epithelial cell response by P. gingivalisR01DE016593 · NIDCR · UNIVERSITY OF FLORIDA · PI YILMAZ, OZLEM · 2006 to 2016
$3.3M
Modulation of Epithelial Cell Response by P. gingivalisR56DE016593 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YILMAZ, OZLEM · 2019 to 2019
$355k
NIDCR NIH HHS R01 DE016593NIDCR NIH HHS R01 DE019783NIDCR NIH HHS R56 DE016593NIDCR NIH HHS T32 DE017551NIDCR NIH HHS T90 DE021990NIGMS NIH HHS P30 GM103331
6 · The paper itself

Abstract

Nucleoside-diphosphate-kinases (NDKs) are leaderless, multifunctional enzymes. The mode(s) of NDK secretion is currently undefined, while extracellular translocation of bacterial NDKs is critical for avoidance of host pathogen clearance by opportunistic pathogens such as Porphyromonas gingivalis. P. gingivalis-NDK during infection inhibits extracellular-ATP (eATP)/P2X

Indexed as

Protein Interaction MappingProtein Sorting SignalsActinsAdenosine TriphosphateAdultBacteroidaceae InfectionsCells, CulturedConnexinsEnzyme-Linked Immunosorbent AssayEpithelial CellsGingivaHumansMass SpectrometryMembrane MicrodomainsMicroscopy, FluorescenceModels, BiologicalActinsAdenosine TriphosphateConnexinsMyosinsNerve Tissue ProteinsNucleoside-Diphosphate KinasePANX1 protein, humanProtein Sorting Signals

Identifiers

PMID27883084
PMCPMC5121656
OpenAlexW2555251529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.