Evidence map›Paper›PMID 27883051›Full record

ArticleScientific reports2016

Lipid Coated Microbubbles and Low Intensity Pulsed Ultrasound Enhance Chondrogenesis of Human Mesenchymal Stem Cells in 3D Printed Scaffolds.

Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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  3. Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mitra AliabouzarDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, 20052, USA.
Lijie Grace ZhangDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, 20052, USA.
Kausik SarkarDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, 20052, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid-coated microbubbles are used to enhance ultrasound imaging and drug delivery. Here we apply these microbubbles along with low intensity pulsed ultrasound (LIPUS) for the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in a 3D printed poly-(ethylene glycol)-diacrylate (PEG-DA) hydrogel scaffold. The hMSC proliferation increased up to 40% after 5 days of culture in the presence of 0.5% (v/v) microbubbles and LIPUS in contrast to 18% with LIPUS alone. We systematically varied the acoustic excitation parameters-excitation intensity, frequency and duty cycle-to find 30 mW/cm

Indexed as

CartilageCell DifferentiationCells, CulturedChondrocytesChondrogenesisCollagen Type IIHumansHydrogel, Polyethylene Glycol DimethacrylateLipidsMesenchymal Stem CellsMicrobubblesOsteogenesisPolyethylene GlycolsPrinting, Three-DimensionalRegenerationTissue EngineeringCollagen Type IIHydrogel, Polyethylene Glycol DimethacrylateLipidspoly(ethylene glycol)diacrylatePolyethylene Glycols

Identifiers

PMID27883051
PMCPMC5121887

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.