Evidence map›Paper›PMID 27882999›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Activation of Ventral Tegmental Area 5-HT

Lourdes Valencia-Torres, Cristian M Olarte-Sánchez, David J Lyons, Teodora Georgescu, Megan Greenwald-Yarnell, Martin G Myers, Christopher M Bradshaw, Lora K Heisler

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Early Life Stress Impairs VTA Coordination of BLA Network and Behavioral States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Serotonin 5-HTFrontiers in neuroscience · 2025
    Article
  4. Article
  5. 5-HTNutrients · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Orexin, serotonin, and energy balance.WIREs mechanisms of disease · 2022
    Review
  11. Serotonin, food intake, and obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Review
  12. Review
  13. Review
  14. Serotonin in Animal Cognition and Behavior.International journal of molecular sciences · 2020
    Review
  15. Dual-mode dopamine increases mediated by 5-HTExperimental brain research · 2019
    Article
  16. Review
  17. Glucagon-Like Peptide-1 (GLP-1) and 5-Hydroxytryptamine 2c (5-HTInternational journal of molecular sciences · 2019
    Article
  18. Article
  19. Neuropharmacology of compulsive eating.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  20. Serotonin 5-HTFrontiers in pharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lourdes Valencia-TorresRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Cristian M Olarte-SánchezRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
David J LyonsRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Teodora GeorgescuRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
Megan Greenwald-YarnellDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Martin G MyersDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Christopher M BradshawDivision of Psychiatry, University of Nottingham, Queen's Medical Centre, Nottingham, UK.
Lora K HeislerRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
University of Aberdeen · GBUniversity of Michigan–Ann Arbor · USUniversity of Nottingham · GB

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALINGR01DK056731 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1999 to 2025
$6.0M
Role of the Lateral Hypothalamic Area in Leptin ActionR01DK078056 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 2008 to 2017
$3.4M
Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK056731NIDDK NIH HHS R01 DK078056NINDS NIH HHS T32 NS076401Wellcome Trust 098012
6 · The paper itself

Abstract

Obesity is primarily due to food intake in excess of the body's energetic requirements, intake that is not only associated with hunger but also the incentive value of food. The 5-hydroxytryptamine 2C receptor (5-HT

Indexed as

AnimalsBenzazepinesConditioning, OperantEatingFemaleMaleMiceMice, TransgenicMotivationReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsVentral Tegmental AreaBenzazepineslorcaserinReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor Agonists

Identifiers

PMID27882999
PMCPMC5362069
OpenAlexW2550591222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.