Evidence map›Paper›PMID 27882998›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Dopamine and Opioid Neurotransmission in Behavioral Addictions: A Comparative PET Study in Pathological Gambling and Binge Eating.

Joonas Majuri, Juho Joutsa, Jarkko Johansson, Valerie Voon, Kati Alakurtti, Riitta Parkkola, Tuuli Lahti, Hannu Alho, Jussi Hirvonen, Eveliina Arponen and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.

  1. Pooled it
  2. Intranasal naloxone rapidly occupies brain mu-opioid receptors in human subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Trial
  3. Article
  4. Infarct-Limiting Efficacy of the μBulletin of experimental biology and medicine · 2026
    Article
  5. Article
  6. Article
  7. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. Similarities and Differences in Neurobiology.Advances in experimental medicine and biology · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. The Role of the Endocannabinoid System in Binge Eating Disorder.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. A literature review of dopamine in binge eating.Journal of eating disorders · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Joonas MajuriDivision of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
Juho JoutsaDivision of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
Jarkko JohanssonTurku PET Centre, University of Turku, Turku, Finland.
Valerie VoonDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Kati AlakurttiTurku PET Centre, University of Turku, Turku, Finland.
Riitta ParkkolaDepartment of Radiology, University of Turku and Turku University Hospital, Turku, Finland.
Tuuli LahtiDepartment of Health, Unit of Tobacco, Alcohol and Gambling, National Institute of Health and Welfare, Helsinki, Finland.
Hannu AlhoDepartment of Health, Unit of Tobacco, Alcohol and Gambling, National Institute of Health and Welfare, Helsinki, Finland.
Jussi HirvonenTurku PET Centre, University of Turku, Turku, Finland.
Eveliina ArponenTurku PET Centre, University of Turku, Turku, Finland.
Sarita ForsbackTurku PET Centre, University of Turku, Turku, Finland.
Valtteri KaasinenDivision of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
University of Turku · FITurku PET Centre · FIFinnish Institute for Health and Welfare · FIUniversity of Cambridge · GB

Funding

Medical Research Council MR/P008747/1Wellcome Trust 093705
6 · The paper itself

Abstract

Although behavioral addictions share many clinical features with drug addictions, they show strikingly large variation in their behavioral phenotypes (such as in uncontrollable gambling or eating). Neurotransmitter function in behavioral addictions is poorly understood, but has important implications in understanding its relationship with substance use disorders and underlying mechanisms of therapeutic efficacy. Here, we compare opioid and dopamine function between two behavioral addiction phenotypes: pathological gambling (PG) and binge eating disorder (BED). Thirty-nine participants (15 PG, 7 BED, and 17 controls) were scanned with [

Indexed as

AdultAnalgesics, OpioidBehavior, AddictiveBrainBulimiaCarbon RadioisotopesDihydroxyphenylalanineDopamineFemaleFentanylGamblingHumansMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsAnalgesics, OpioidCarbon RadioisotopescarfentanilDihydroxyphenylalanineDopamineFentanylfluorodopa F 18Radiopharmaceuticals

Identifiers

PMID27882998
PMCPMC5357051
OpenAlexW2545618671

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.