ReviewWiley interdisciplinary reviews. Developmental biology2017
The cellular and molecular basis of cnidarian neurogenesis.
Review in Wiley interdisciplinary reviews. Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 111 citations in OpenAlex.
- Revisiting nerve nets: functional organization and evolutionary implications.The EMBO journal · 2026Review
- Functional Analysis of Ligand-Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Lineage-specific elaboration of a conserved cnidogenic program drives cnidocyte diversification and illuminates cell type evolution.Research square · 2026Article
- Deciphering the ancestral mechanisms of neural regeneration through single-cell analyses of jellyfish rhopalium repair.Science advances · 2026Article
- The anti-neural role of BMP signaling is a consequence of its ancestral function in dorsoventral patterning.PLoS biology · 2026Article
- FromCells · 2026Review
- NvashA function reveals temporal differences in neural subtype generation in cnidarians.Scientific reports · 2026Article
- Microrna Expression inMicroRNA (Shariqah, United Arab Emirates) · 2026Article
- Diffuse pacemaker mechanism with distinctive organization drives pulsation in the octocoralProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Heat Stress Drives Rapid Viral and Antiviral Innate Immunity Activation in Hexacorallia.Molecular ecology · 2025Article
- That Stinging Sensation: Modularity and the Origin of the Stinging Cell.Integrative and comparative biology · 2025Review
- How Single-Cell Transcriptomics of Hydractinia Is Informing the Evolution of Cnidarian Sensory Systems.Integrative and comparative biology · 2025Review
- Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- A whole-body atlas of BMP signaling activity in an adult sea anemone.BMC biology · 2025Article
- Beyond the canonical niche: how astrocytes carried neurogenic potential into the brain parenchyma.Frontiers in cell and developmental biology · 2025Review
- Terminal differentiation precedes functional circuit integration in the peduncle neurons in regenerating Hydra vulgaris.Neural development · 2024Article
- A wound-induced differentiation trajectory for neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Doublecortin-like kinase is required for cnidocyte development in Nematostella vectensis.Neural development · 2024Article
- Larval swimming in the sea anemoneEcology and evolution · 2024Article
- Updated single cell reference atlas for the starlet anemone Nematostella vectensis.Frontiers in zoology · 2024Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Neurogenesis initiates during early development and it continues through later developmental stages and in adult animals to enable expansion, remodeling, and homeostasis of the nervous system. The generation of nerve cells has been analyzed in detail in few bilaterian model organisms, leaving open many questions about the evolution of this process. As the sister group to bilaterians, cnidarians occupy an informative phylogenetic position to address the early evolution of cellular and molecular aspects of neurogenesis and to understand common principles of neural development. Here we review studies in several cnidarian model systems that have revealed significant similarities and interesting differences compared to neurogenesis in bilaterian species, and between different cnidarian taxa. Cnidarian neurogenesis is currently best understood in the sea anemone Nematostella vectensis, where it includes epithelial neural progenitor cells that express transcription factors of the soxB and atonal families. Notch signaling regulates the number of these neural progenitor cells, achaete-scute and dmrt genes are required for their further development and Wnt and BMP signaling appear to be involved in the patterning of the nervous system. In contrast to many vertebrates and Drosophila, cnidarians have a high capacity to generate neurons throughout their lifetime and during regeneration. Utilizing this feature of cnidarian biology will likely allow gaining new insights into the similarities and differences of embryonic and regenerative neurogenesis. The use of different cnidarian model systems and their expanding experimental toolkits will thus continue to provide a better understanding of evolutionary and developmental aspects of nervous system formation. WIREs Dev Biol 2017, 6:e257. doi: 10.1002/wdev.257 For further resources related to this article, please visit the WIREs website.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.