Evidence map›Paper›PMID 27882681›Full record

ArticleCancer medicine2017

General practice consultations, diagnostic investigations, and prescriptions in the year preceding a lung cancer diagnosis.

Louise M Guldbrandt, Henrik Møller, Erik Jakobsen, Peter Vedsted

Abstract read
In one paragraph

Article in Cancer medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Prediagnostic prescription patterns in pancreatic cancer: a retrospective primary care cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Article
  2. Prediagnostic primary care consultations and imaging in emergency-diagnosed versus referred patients with lung cancer: a population-based linked data study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Achieving earlier diagnosis of symptomatic lung cancer.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
    Article
  8. Clinical activity in general practice before sarcoma diagnosis: an Australian cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Associations between general practice characteristics and chest X-ray rate: an observational study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022
    Observational
  13. Article
  14. Article
  15. Article
  16. Electronic patient records research to aid diagnostic reasoning for possible cancer in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Louise M GuldbrandtResearch Centre for Cancer Diagnosis in Primary Care, Research Unit for General Practice, Aarhus University, Denmark.
Henrik MøllerResearch Centre for Cancer Diagnosis in Primary Care, Research Unit for General Practice, Aarhus University, Denmark.
Erik JakobsenDepartment of Thoracic Surgery, Odense University Hospital, Denmark.
Peter VedstedResearch Centre for Cancer Diagnosis in Primary Care, Research Unit for General Practice, Aarhus University, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patterns of general practice utilization in the period before lung cancer (LC) diagnosis may provide new knowledge to ensure timelier and earlier diagnosis of LC. This study aimed to explore the prediagnostic activity in general practice in the year preceding LC diagnosis. The activity was compared to a matched comparison group. We compared LC patients with different stage, and patients with and without chronic obstructive pulmonary disease (COPD). Using Danish registers, we performed a population-based matched cohort study including lung cancer patients (n = 34,017) and matched comparison subjects (n = 340,170). During months 12 to 1 prior to diagnosis, 92.6% of LC patients and 88.4% of comparison subjects had one or more contacts with general practice. 13.0% of LC patients and 3.3% of comparison subjects had two or more X-rays. 20.8% of LC patients and 8.5% of comparison subjects had two or more first-time antibiotics prescriptions. The incidence rate ratio for having a contact to general practice was similar for LC patients with localized disease compared to LC patients with metastatic disease. LC patients with COPD had more frequent contacts, lung functions tests, X-rays, and prescriptions than COPD patients without lung cancer, but not as pronounced as compared to patients without COPD. There was a significant increase in healthcare seeking and diagnostic activity in the year prior to a LC diagnosis, regardless of stage at diagnosis. COPD may mask the symptoms of LC. This indicates the presence of a "diagnostic time window" and a potential for more timely diagnosis of LC based on clinical signs and symptoms.

Indexed as

AdultAgedCohort StudiesDenmarkDrug PrescriptionsEarly Detection of CancerFemaleGeneral PracticeHumansLung NeoplasmsMaleMiddle AgedPulmonary Disease, Chronic ObstructiveReferral and ConsultationRegistriesCOPDdiagnosisearly diagnosisgeneral practicelung cancer

Identifiers

PMID27882681
PMCPMC5269702

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.