Evidence map›Paper›PMID 27882633›Full record

ArticleAngewandte Chemie (International ed. in English)2016

Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density.

Shaoheng Tang, Chuanqi Peng, Jing Xu, Bujie Du, Qingxiao Wang, Rodrigo D Vinluan, Mengxiao Yu, Moon J Kim, Jie Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Targeted therapeutic strategies for the kidney.Expert opinion on therapeutic targets · 2024
    Review
  9. Review
  10. Review
  11. Targeted nanotherapy for kidney diseases: a comprehensive review.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Review
  18. Salivary Excretion of Renal-Clearable Silver Nanoparticles.Angewandte Chemie (International ed. in English) · 2020
    Article
  19. Review
  20. Nanoparticle contrast agents for X-ray imaging applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shaoheng TangDepartment of Chemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Chuanqi PengDepartment of Chemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Jing XuDepartment of Chemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Bujie DuDepartment of Chemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Qingxiao WangDepartment of Materials Science and Engineering, The University of Texas at Dallas, USA.
Rodrigo D VinluanDepartment of Chemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Mengxiao YuDepartment of Chemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Moon J KimDepartment of Materials Science and Engineering, The University of Texas at Dallas, USA.
Jie ZhengDepartment of Chemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.

Funding

Surface chemistry for high-contrast fluorescence kidney imagingR01DK103363 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI ZHENG, JIE · 2014 to 2018
$1.3M
NIDDK NIH HHS R01 DK103363
6 · The paper itself

Abstract

Identifying key factors that govern the in vivo behavior of nanomaterials is critical to the clinical translation of nanomedicines. Overshadowed by size-, shape-, and surface-chemistry effects, the impact of the particle core density on clearance and tumor targeting of inorganic nanoparticles (NPs) remains largely unknown. By utilizing a class of ultrasmall metal NPs with the same size and surface chemistry but different densities, we found that the renal-clearance efficiency exponentially increased in the early elimination phase while passive tumor targeting linearly decreased with a decrease in particle density. Moreover, lower-density NPs are more easily distributed in the body and have shorter retention times in highly permeable organs than higher-density NPs. The density-dependent in vivo behavior of metal NPs likely results from their distinct margination in laminar blood flow, which opens up a new path for precise control of nanomedicines in vivo.

Indexed as

GlutathioneGoldHumansKidneyMetal NanoparticlesNeoplasmsParticle SizeSilverSurface PropertiesGlutathioneGoldSilverfluorescence imagingimaging agentsnanoparticlesrenal clearancetumor targeting

Identifiers

PMID27882633
PMCPMC5285510

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.