Evidence map›Paper›PMID 27882537›Full record

ArticleBritish journal of pharmacology2017

Neurochemical and behavioural effects of hypidone hydrochloride (YL-0919): a novel combined selective 5-HT reuptake inhibitor and partial 5-HT

Li-Ming Zhang, Xiao-Yun Wang, Nan Zhao, Yu-Lu Wang, Xiao-Xu Hu, Yu-Hua Ran, Yan-Qin Liu, You-Zhi Zhang, Ri-Fang Yang, Yun-Feng Li

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. GW117: A novel serotonin (5-HTCNS neuroscience & therapeutics · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. YL-0919, a dual 5-HTActa pharmacologica Sinica · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Li-Ming ZhangDepartment of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Xiao-Yun WangDepartment of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Nan ZhaoDepartment of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Yu-Lu WangDepartment of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Xiao-Xu HuDepartment of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Yu-Hua RanDepartment of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Yan-Qin LiuDepartment of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
You-Zhi ZhangDepartment of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Ri-Fang YangDepartment of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Yun-Feng LiDepartment of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
First Affiliated Hospital of Zhengzhou University · CNFujian University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeOur previous studies revealed that hypidone hydrochloride (YL-0919), which acts as a selective 5-HT (serotonin) reuptake inhibitor (SSRI) and displays partial 5-HT EXPERIMENTAL APPROACH: We first investigated the target profile of YL-0919 using [ KEY

resultsData from the present study demonstrated that YL-0919 displays partial 5-HT CONCLUSIONS AND IMPLICATIONS: These data suggest that YL-0919 is probably a fast-onset potent antidepressant with few side effects.

Indexed as

Drug Partial AgonismAnimalsAnti-Anxiety AgentsAntidepressive AgentsAvoidance LearningDose-Response Relationship, DrugFemaleHippocampusMaleMiceMice, Inbred ICRMicrodialysisPiperidinesPyridonesRatsRats, Sprague-Dawley1-(1-benzyl-4-hydroxypiperidin-4-ylmethyl)-2(1H)-pyridinoneAnti-Anxiety AgentsAntidepressive AgentsPiperidinesPyridonesReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsSerotonin 5-HT1 Receptor Agonists

Identifiers

PMID27882537
PMCPMC5386994
OpenAlexW2555039283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.