ArticleBrain imaging and behavior2017
Diametrical relationship between gray and white matter volumes in autism spectrum disorder and schizophrenia.
Article in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- The relationships between anxiety, psychotic-like experiences and autism: a systematic review.Frontiers in psychology · 2025Pooled it
- Autism spectrum disorder and schizophrenia: An updated conceptual review.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Associations between antagonistic SNPs for neuropsychiatric disorders and human brain structure.Translational psychiatry · 2024Article
- Assessment of Neuroanatomical Endophenotypes of Autism Spectrum Disorder and Association With Characteristics of Individuals With Schizophrenia and the General Population.JAMA psychiatry · 2023Article
- Application of a Machine Learning Algorithm for Structural Brain Images in Chronic Schizophrenia to Earlier Clinical Stages of Psychosis and Autism Spectrum Disorder: A Multiprotocol Imaging Dataset Study.Schizophrenia bulletin · 2022Article
- Developmental brain structural atypicalities in autism: a voxel-based morphometry analysis.Child and adolescent psychiatry and mental health · 2022Article
- Oligodendrocyte lineage cells and depression.Molecular psychiatry · 2021Review
- Theory of Mind (ToM) Performance in High Functioning Autism (HFA) and Schizotypal-Schizoid Personality Disorders (SSPD) Patients.Journal of autism and developmental disorders · 2019Article
- Clinical Profiles and Conversion Rates Among Young Individuals With Autism Spectrum Disorder Who Present to Clinical High Risk for Psychosis Services.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Neuroanatomical deficits shared by youth with autism spectrum disorders and psychotic disorders.Human brain mapping · 2019Article
- Dynamic functional connectivity in schizophrenia and autism spectrum disorder: Convergence, divergence and classification.NeuroImage. Clinical · 2019Article
- Increased white matter metabolic rates in autism spectrum disorder and schizophrenia.Brain imaging and behavior · 2018Article
- Diametric effects of autism tendencies and psychosis proneness on attention control irrespective of task demands.Scientific reports · 2018Article
- Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia.Brain imaging and behavior · 2018Article
- Social Cognition in Schizophrenia and Autism Spectrum Disorders: A Systematic Review and Meta-Analysis of Direct Comparisons.Frontiers in psychiatry · 2018Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Autism spectrum disorders and schizophrenia have been variously characterized as separate nosological entities with overlapping deficits in social cognition or diametrical extremes of a phenotypic continuum. This study aimed to determine how these models apply to comparative morphometric data. MRI scans of the brain were obtained in 49 subjects with schizophrenia, 20 subjects with autism and 39 healthy controls. Images were parcellated into 40 Brodmann areas and entered into repeated-measures ANOVA for between-group comparison of global and localized gray and white matter volumes. A pattern of lower gray mater volumes and greater white matter volumes was found in subjects with schizophrenia in comparison to subjects with autism. For both gray and white matter, this pattern was most pronounced in regions associated with motor-premotor and anterior frontal cortex, anterior cingulate, fusiform, superior and middle temporal gyri. Patient groups tended to diverge from healthy controls in opposite directions, with greater-than-normal gray matter volumes and lower-than-normal white matter volumes in subjects with autism and reversed patterns in subjects with schizophrenia. White matter reductions in subjects with autism were seen in posterior frontal lobe and along the cingulate arch. Normal hemispheric asymmetry in the temporal lobe was effaced in subjects with autism and schizophrenia, especially in the latter. Nearly identical distribution of changes and diametrically divergent volumetry suggest that autism and schizophrenia may occupy opposite extremes of the same cognitive continuum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.