Evidence map›Paper›PMID 27882334›Full record

ReviewJournal of immunology research2016

Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment.

Fabian Flores-Borja, Sheeba Irshad, Peter Gordon, Felix Wong, Ibrahim Sheriff, Andrew Tutt, Tony Ng

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fabian Flores-BorjaBreast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK.ORCID 0000-0002-0881-8822
Sheeba IrshadBreast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK.
Peter GordonBreast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK.
Felix WongRichard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, King's College London, Guy's Medical School Campus, London SE1 1ULK, UK.
Ibrahim SheriffRichard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, King's College London, Guy's Medical School Campus, London SE1 1ULK, UK.
Andrew TuttBreast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK; Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London SW3 6JB, UK.
Tony NgBreast Cancer Now Research Unit, Division of Cancer Studies, Guy's Hospital, King's College London School of Medicine, London SE1 9RT, UK; Richard Dimbleby Department of Cancer Research, Randall Division & Division of Cancer Studies, King's College London, Guy's Medical School Campus, London SE1 1ULK, UK; UCL Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK.
Guy's Hospital · GBKing's College London · GB

Funding

Cancer Research UK 16463
6 · The paper itself

Abstract

Our knowledge and understanding of the tumor microenvironment (TME) have been recently expanded with the recognition of the important role of innate lymphoid cells (ILC). Three different groups of ILC have been described based on their ability to produce cytokines that mediate the interactions between innate and adaptive immune cells in a variety of immune responses in infection, allergy, and autoimmunity. However, recent evidence from experimental models and clinical studies has demonstrated that ILC contribute to the mechanisms that generate suppressive or tolerant environments that allow tumor regression or progression. Defining the complex network of interactions and crosstalk of ILC with other immune cells and understanding the specific contributions of each type of ILC leading to tumor development will allow the manipulation of their function and will be important to develop new interventions and therapeutic strategies.

Indexed as

Immunity, InnateAnimalsBiomarkersCell CommunicationCell MovementCell TrackingHumansLymphocyte ActivationLymphocyte SubsetsNeoplasmsOrgan SpecificityTumor MicroenvironmentBiomarkers

Identifiers

PMID27882334
PMCPMC5110869
OpenAlexW2530255522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.