SynthesisNeuroImage. Clinical2016
White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis.
Synthesis in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy.Annals of clinical and translational neurology · 2026Article
- Multimodal integration of magnetic resonance imaging and intracranial electroencephalographic abnormalities in temporal lobe epilepsy surgery.Epilepsia · 2026Article
- Extremely/Very Premature Birth Associated With Focal Epileptic Activity in Comorbid Autism and Epilepsy.Journal of child neurology · 2026Article
- Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery.Epilepsia · 2025Article
- Assessment of cerebral drug occupancy in humans using a single PET-scan: A [European journal of nuclear medicine and molecular imaging · 2024Observational
- Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Association of neighborhood deprivation with white matter connectome abnormalities in temporal lobe epilepsy.Epilepsia · 2023Article
- Multiparametric mapping of white matter reorganizations in patients with frontal glioma-related epilepsy.CNS neuroscience & therapeutics · 2023Article
- Diffusion tensor-based analysis of white matter in dogs with idiopathic epilepsy.Frontiers in veterinary science · 2023Article
- Multi-spectral diffusion MRI mega-analysis in genetic generalized epilepsy: Relation to outcomes.NeuroImage. Clinical · 2023Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- Network phenotypes and their clinical significance in temporal lobe epilepsy using machine learning applications to morphological and functional graph theory metrics.Scientific reports · 2022Article
- Bilateral Structural Network Abnormalities in Epilepsy Associated With Bottom-of-Sulcus Dysplasia.Neurology · 2022Article
- White matter alterations in focal to bilateral tonic-clonic seizures.Frontiers in neurology · 2022Article
- Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy.Nature reviews. Neurology · 2021Review
- Probabilistic mapping of thalamic nuclei and thalamocortical functional connectivity in idiopathic generalised epilepsy.Human brain mapping · 2021Article
- Multivariate white matter alterations are associated with epilepsy duration.The European journal of neuroscience · 2021Article
- White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study.Brain : a journal of neurology · 2020Article
- Network, clinical and sociodemographic features of cognitive phenotypes in temporal lobe epilepsy.NeuroImage. Clinical · 2020Article
- NR4A1 Methylation Associated Multimodal Neuroimaging Patterns Impaired in Temporal Lobe Epilepsy.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSince the introduction of diffusion tensor imaging, white matter abnormalities in epilepsy have been studied extensively. However, the affected areas reported, the extent of abnormalities and the association with relevant clinical parameters are highly variable. We aimed to obtain a more consistent estimate of white matter abnormalities and their association with clinical parameters in different epilepsy types.
methodsWe systematically searched for differences in white matter fractional anisotropy and mean diffusivity, at regional and voxel level, between people with epilepsy and healthy controls. Meta-analyses were used to quantify the directionality and extent of these differences. Correlations between white matter differences and age of epilepsy onset, duration of epilepsy and sex were assessed with meta-regressions.
resultsForty-two studies, with 1027 people with epilepsy and 1122 controls, were included with regional data. Sixteen voxel-based studies were also included. People with temporal or frontal lobe epilepsy had significantly decreased fractional anisotropy (Δ -0.021, 95% confidence interval -0.026 to -0.016) and increased mean diffusivity (Δ0.026 × 10 SIGNIFICANCE: This study provides a better estimation of white matter changes in different epilepsies. Effects are particularly found in people with focal epilepsy. Correlations with the duration of focal epilepsy support the hypothesis that these changes are, at least partly, a consequence of seizures and may warrant early surgery. Future studies need to guarantee adequate group sizes, as white matter differences in epilepsy are small.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.