Evidence map›Paper›PMID 27882240›Full record

ArticleJournal of therapeutic ultrasound2016

T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound.

Eugene Ozhinsky, Misung Han, Matthew Bucknor, Roland Krug, Viola Rieke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of therapeutic ultrasound, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Technical advances in motion-robust MR thermometry.Magnetic resonance in medicine · 2024
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. T2 mapping as a predictor of nonperfused volume in MRgFUS treatment of desmoid tumors.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eugene OzhinskyDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, Box 0946, San Francisco, CA 94107 USA.ORCID 0000-0001-8993-7905
Misung HanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, Box 0946, San Francisco, CA 94107 USA.
Matthew BucknorDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, Box 0946, San Francisco, CA 94107 USA.
Roland KrugDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, Box 0946, San Francisco, CA 94107 USA.
Viola RiekeDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, Box 0946, San Francisco, CA 94107 USA.

Funding

UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0M
MRI-Guided Cardiac Focused Ultrasound AblationR00HL097030 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RIEKE, VIOLA · 2012 to 2015
$724k
NHLBI NIH HHS R00 HL097030NIAMS NIH HHS P30 AR066262
6 · The paper itself

Abstract

backgroundCurrent clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjacent muscle to estimate the temperature of the bone. The goal of this study was to determine if T2-based thermometry could be used to monitor the temperature change in bone marrow during focused ultrasound ablation of bone lesions.

methodsWe investigated the dependence of T2 on temperature in ex vivo bovine yellow bone marrow at 3T and studied the influence of acquisition parameters on the T2 measurements. We examined if T2 changes in red bone marrow caused by the ablation of ex vivo trabecular bone were reversible and measured the patterns of heating and tissue damage. The technique was validated during the ablation of intact ex vivo bone samples and an in vivo animal model.

resultsResults of the calibration experiment showed a linear relationship (7 ms/°C) between T2 change and temperature and could be used to quantify the temperature during heating of up to 60 °C. During trabecular bone ablation, we observed a linear relationship (5.7 ms per °C) between T2 and temperature during the heating stage of the experiment. After cool down, there was residual T2 elevation (~35 ms) in the ablated area suggesting irreversible tissue changes. In ex vivo and in vivo cortical bone ablation experiments, we observed an increase in T2 values in the marrow adjacent to the intersection of the cortical bone and the beam path. The in vivo experiment showed excellent correspondence between the area of T2 elevation in marrow during the ablation and the resulting non-enhancing area in the post-contrast images.

conclusionsIn this study, we have demonstrated that T2-based thermometry can be used in vivo to measure the heating in the marrow during bone ablation. The ability to monitor the temperature within the bone marrow allowed more complete visualization of the heat distribution into the bone, which is important for local lesion control.

Indexed as

Bone marrowHIFUMR-guided focused ultrasoundMR thermometryT2 mapping

Identifiers

PMID27882240
PMCPMC5112680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.