ReviewAddiction & health2016
Maternal Separation and the Risk of Drug Abuse in Later Life.
Review in Addiction & health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How childhood adversity affects components of decision making.Neuroscience and biobehavioral reviews · 2025Pooled it
- Maternal deprivation and adolescent alcohol exposure induce sex-dependent alterations in stress-related behavior and lipid signaling in rats.Biology of sex differences · 2026Article
- The oxytocin system mediates behavioral and neurobiological alterations associated with early adversity.Molecular psychiatry · 2026Article
- Adverse childhood experiences, insecure attachment, and appointment compliance in an outpatient addiction psychiatry treatment population.The American journal on addictions · 2025Article
- Early Life Stress Impairs VTA Coordination of BLA Network and Behavioral States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Primal Prevention of Drug Abuse: An Emerging but Unrecognized Public Health Issue.Addiction & health · 2025Article
- Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms.Biomedicines · 2024Review
- Identifying the challenges of policy content related to high-risk sexual behaviors, stimulant drugs, and alcohol consumption in adolescents.BMC health services research · 2024Article
- Levels of BDNF and NGF in adolescent rat hippocampus neonatally exposed to methamphetamine along with environmental alterations.Physiological research · 2023Article
- Lasting impact of postnatal maternal separation on the developing BNST: Lifelong socioemotional consequences.Neuropharmacology · 2023Review
- Communal nesting differentially attenuates the impact of pre-weaning social isolation on behavior in male and female rats during adolescence and adulthood.Frontiers in behavioral neuroscience · 2023Article
- Prolonged Maternal Separation Reduces Anxiety State and Increases Compulsive Burying Activity in the Offspring of BALB/c Mice.Journal of personalized medicine · 2022Article
- Maternal Separation Alters Ethanol Drinking and Reversal Learning Processes in Adolescent Rats: The Impact of Sex and Glycine Transporter Type 1 (GlyT1) Inhibitor.International journal of molecular sciences · 2022Article
- Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice.Frontiers in pharmacology · 2022Article
- Effect of early life social adversity on drug abuse vulnerability: Focus on corticotropin-releasing factor and oxytocin.Neuropharmacology · 2021Review
- The relevance of a rodent cohort in the Consortium on Individual Development.Developmental cognitive neuroscience · 2020Article
- Early-life stress affects drug abuse susceptibility in adolescent rat model independently of depression vulnerability.Scientific reports · 2020Article
- Stress, sensitive periods, and substance abuse.Neurobiology of stress · 2019Review
- Negative consequences of early-life adversity on substance use as mediated by corticotropin-releasing factor modulation of serotonin activity.Neurobiology of stress · 2018Review
- Early-life adversity selectively impairs α2-GABANeuropharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal separation (MS) is defined as the termination of the continuity of mother-child relationship after the relationship is established. Although MS and maternal deprivation are different in terms of their definitions, these two terms are usually used interchangeably. This review aims to investigate the effect of MS on drug intake in adulthood. It has been proved that animal models are helpful in evaluating the effects of MS on drug intake risk in adulthood. There are relatively acceptable studies in this field on some drugs such as morphine, ethanol, and cocaine. However, very few animal studies, or even no animal study, have been conducted on some other drugs. The majority of these studies have considered MS as a risk factor for drug intake in adulthood. Different mechanisms are proposed for this phenomenon. Brain reward pathways are one of the main exploratory pathways of this process. Despite the importance of the issue, no human study with a specific concentration on investigating the relationship between MS and drug abuse in later life was found. Causal studies are warranted on humans to investigate the effect of MS on drug intake in later life.
Indexed as
Identifiers
27882208PMC5115644What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.