Evidence map›Paper›PMID 27882091›Full record

ArticleExperimental and therapeutic medicine2016

Exendin-4 antagonizes Aβ1-42-induced attenuation of spatial learning and memory ability.

Xiaohui Wang, Li Wang, Ruirui Jiang, Yunyun Xu, Xueling Zhao, Yang Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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  14. Exendin-4 alleviates β-Amyloid peptide toxicityFrontiers in aging neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaohui WangDepartment of Pathology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Li WangDepartment of Pathology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Ruirui JiangDepartment of Pathology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Yunyun XuDepartment of Pathology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Xueling ZhaoDepartment of Pathology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Yang LiDepartment of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Shanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-amyloid protein (Aβ) accumulation in cerebral centers involved in cognition and memory is a pivotal pathological feature of Alzheimer's disease (AD). The onset process of type 2 diabetes mellitus (T2DM) has a number of similarities compared with AD. Thus, it is hypothesized that the pharmacological therapy employed for the treatment of T2DM may help to prevent and ameliorate the symptoms of AD. This study demonstrated that Exendin-4, which is a glucagon-like peptide-1 analogue which is used as a therapeutic drug for T2DM, markedly antagonized Aβ fragment-induced attenuation of spatial learning and memory ability, as indicated by a Morris water maze experiment. In addition, we investigated the potential underlying electrophysiological and molecular mechanisms. The results indicate that Exendin-4 rescued long-term potentiation from Aβ1-42-induced damage in the rat hippocampal CA1 region

Indexed as

Exendin-4mechanismneuroprotectionβ-amyloid protein 1-42

Identifiers

PMID27882091
PMCPMC5103720
OpenAlexW2523197849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.