Evidence map›Paper›PMID 27881978›Full record

ArticleFrontiers in microbiology2016

The Oxidosqualene Cyclase from the Oomycete

Paul Dahlin, Vaibhav Srivastava, Vincent Bulone, Lauren S McKee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Genome-Wide Analysis of Oxidosqualene Cyclase Genes inCurrent issues in molecular biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Paul DahlinDivision of Glycoscience, School of Biotechnology, KTH Royal Institute of TechnologyStockholm, Sweden; Department of Ecology, Environment and Plant Sciences, Stockholm UniversityStockholm, Sweden.
Vaibhav SrivastavaDivision of Glycoscience, School of Biotechnology, KTH Royal Institute of Technology Stockholm, Sweden.
Vincent BuloneDivision of Glycoscience, School of Biotechnology, KTH Royal Institute of TechnologyStockholm, Sweden; ARC Centre of Excellence in Plant Cell Walls, School of Agriculture, Food and Wine, The University of Adelaide, UrrbraeSA, Australia.
Lauren S McKeeDivision of Glycoscience, School of Biotechnology, KTH Royal Institute of TechnologyStockholm, Sweden; Wallenberg Wood Science Centre, KTH Royal Institute of TechnologyStockholm, Sweden.
KTH Royal Institute of Technology · SEUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first committed step of sterol biosynthesis is the cyclisation of 2,3-oxidosqualene to form either lanosterol (LA) or cycloartenol (CA). This is catalyzed by an oxidosqualene cyclase (OSC). LA and CA are subsequently converted into various sterols by a series of enzyme reactions. The specificity of the OSC therefore determines the final composition of the end sterols of an organism. Despite the functional importance of OSCs, the determinants of their specificity are not well understood. In sterol-synthesizing oomycetes, recent bioinformatics, and metabolite analysis suggest that LA is produced. However, this catalytic activity has never been experimentally demonstrated. Here, we show that the OSC of the oomycete

Indexed as

lanosterol biosynthesisoomyceteoxidosqualene cyclaseSaprolegnia parasiticasterols

Identifiers

PMID27881978
PMCPMC5101207
OpenAlexW2556603580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.