Evidence map›Paper›PMID 27881971›Full record

ArticleFrontiers in endocrinology2016

Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

Evie van der Spoel, Ferdinand Roelfsema, Steffy W Jansen, Abimbola A Akintola, Bart E Ballieux, Christa M Cobbaert, Gerard J Blauw, P Eline Slagboom, Rudi G J Westendorp, Hanno Pijl and 1 more

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In one paragraph

Article in Frontiers in endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Evie van der SpoelSection Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center , Leiden , Netherlands.
Ferdinand RoelfsemaSection Endocrinology, Department of Internal Medicine, Leiden University Medical Center , Leiden , Netherlands.
Steffy W JansenSection Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center , Leiden , Netherlands.
Abimbola A AkintolaSection Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center , Leiden , Netherlands.
Bart E BallieuxDepartment of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center , Leiden , Netherlands.
Christa M CobbaertDepartment of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center , Leiden , Netherlands.
Gerard J BlauwSection Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center , Leiden , Netherlands.
P Eline SlagboomSection Molecular Epidemiology, Department of Medical Statistics, Leiden University Medical Center , Leiden , Netherlands.
Rudi G J WestendorpSection Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands; Department of Public Health, Center of Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Hanno PijlSection Endocrinology, Department of Internal Medicine, Leiden University Medical Center , Leiden , Netherlands.
Diana van HeemstSection Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center , Leiden , Netherlands.
Leiden University Medical Center · NLUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextA trade-off between fertility and longevity possibly exists. The association of the male hypothalamic-pituitary-gonadal (HPG) axis with familial longevity has not yet been investigated.

objectiveTo study 24-h hormone concentration profiles of the HPG axis in men enriched for familial longevity and controls.

designWe frequently sampled blood over 24 h in 10 healthy middle-aged male offspring of nonagenarian participants from the Leiden Longevity Study together with 10 male age-matched controls. Individual 24-h luteinizing hormone (LH) and testosterone concentration profiles were analyzed by deconvolution analyses to estimate secretion parameters. Furthermore, the temporal relationship between LH and testosterone was assessed by cross-correlation analysis. We used (cross-)approximate entropy to quantify the strength of feedback and/or feedforward control of LH and testosterone secretion.

resultsMean [95% confidence interval (CI)] total LH secretion of the offspring was 212 (156-268) U/L/24 h, which did not differ significantly (

conclusionThis relatively small study suggests that in healthy male middle-aged participants, familial longevity is not associated with major differences in the HPG axis. Selection on both fertility and health may in part explain the results.

Indexed as

approximate entropyfamilial longevityhormone secretionhypothalamic–pituitary–gonadal axisluteinizing hormonetemporal correlationtestosterone

Identifiers

PMID27881971
PMCPMC5101217
OpenAlexW2550548555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.