Evidence map›Paper›PMID 27881906›Full record

ArticleMolecular vision2016

Genetic and immunohistochemical analysis of HSPA5 in mouse and human retinas.

Sumana R Chintalapudi, XiaoFei Wang, Huiling Li, Yin H Chan Lau, Robert W Williams, Monica M Jablonski

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Molecular vision, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Novel photoreceptor-specific promoters for gene therapy in mid- to late-stage retinal degeneration.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sumana R ChintalapudiDepartment of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN; Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN.
XiaoFei WangDepartment of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN.
Huiling LiDepartment of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN; Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yin H Chan LauDepartment of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN.
Robert W WilliamsDepartment of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN; Department of Genetics, Genomics and Informatics, The University of Tennessee Health Science Center, Memphis, TN.
Monica M JablonskiDepartment of Ophthalmology, Hamilton Eye Institute, The University of Tennessee Health Science Center, Memphis, TN; Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN; Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN.

Funding

CORE--MOLECULAR BIOLOGYP30EY013080 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JOHNSON, DIANNA AMMONS · 2000 to 2010
$3.7M
Genetic Modulators of GlaucomaR01EY021200 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JABLONSKI, MONICA M · 2011 to 2022
$3.2M
NEI NIH HHS P30 EY013080NEI NIH HHS R01 EY021200
6 · The paper itself

Abstract

purposePhotoreceptor degenerative diseases are among the leading causes of vision loss. Although the causative genetic mutations are often known, mechanisms leading to photoreceptor degeneration remain poorly defined. We have previously demonstrated that the photoreceptor membrane-associated protein XAP-1 antigen is a product of the

methodsQuantitative trait locus (QTL) mapping was used to map the genomic region that regulates

resultsIn the eyes of healthy mice, extracellular HSPA5 was confined to the area around the cone photoreceptor outer segments. Mapping variation in

conclusionsWe identified

Indexed as

AgedAged, 80 and overAnimalsComputational BiologyEndoplasmic Reticulum Chaperone BiPFemaleGene Expression RegulationGenetic Association StudiesHeat-Shock ProteinsHumansImmunohistochemistryMaleMiceRetinaSulfatasesTissue DonorsEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, humanHspa5 protein, mouseSulf2 protein, mouseSulfatases

Identifiers

PMID27881906
PMCPMC5108462

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.