Evidence map›Paper›PMID 27881867›Full record

ArticleScientific reports2016

Endothelial cell colony forming units derived from malignant breast diseases are resistant to tumor necrosis factor-α-induced apoptosis.

Chen-Pin Chou, Shih Sheng Jiang, Huay-Ben Pan, Yi-Chen Yen, Hui-Hwa Tseng, Yu-Ting Hung, Ssu-Han Wang, Yu-Lin Chen, Ya-Wen Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Chen-Pin ChouDepartment of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Shih Sheng JiangNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Huay-Ben PanDepartment of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Yi-Chen YenNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Hui-Hwa TsengSchool of Medicine, National Yang-Ming University, Taipei, Taiwan.
Yu-Ting HungDepartment of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Ssu-Han WangNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Yu-Lin ChenNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Ya-Wen ChenNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
National Health Research Institutes · TWKaohsiung Veterans General Hospital · TWChina Medical University · TWNational Yang Ming Chiao Tung University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mobilisation of endothelial progenitor cells (EPCs) from the bone marrow is a crucial step in the formation of de novo blood vessels, and levels of peripheral blood EPCs have been shown to be elevated in certain malignant states. Using flow cytometry and a Hill-based colony forming unit (CFU) assay, the present study indicated that higher levels of CD34 and vascular endothelial growth factor receptor 2 (VEGFR2) double-positive EPCs, as well as increased formation of endothelial cell colony-forming units (EC-CFUs) are associated with benign and malignant breast diseases, providing possible indicators for breast disease detection. Gene expression profiles revealed a genetic difference between CD34

Indexed as

Gene Expression Regulation, NeoplasticAdultAntigens, CD34ApoptosisBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularCarcinoma, PapillaryCase-Control StudiesColony-Forming Units AssayDiagnosis, DifferentialDisease ResistanceEndothelial Progenitor CellsFemaleGene Expression ProfilingHumansAntigens, CD34KDR protein, humanReceptors, Tumor Necrosis Factor, Type IITumor Necrosis Factor-alphaVascular Endothelial Growth Factor Receptor-2

Identifiers

PMID27881867
PMCPMC5121583
OpenAlexW2551714266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.