Evidence map›Paper›PMID 27881856›Full record

ReviewNature reviews. Neuroscience2017

Stress, glucocorticoids and memory: implications for treating fear-related disorders.

Dominique de Quervain, Lars Schwabe, Benno Roozendaal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Cortisol suppression impairs retrieval of emotional memory and changes its neural correlates immediately and four days post-treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  12. Randomized controlled experimental study of hydrocortisone and D-cycloserine effects on fear extinction in PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Trial
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  14. Acute stress leaves fear generalization in healthy individuals intact.Cognitive, affective & behavioral neuroscience · 2021
    Trial
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  16. Distinct Roles of Dopamine and Noradrenaline in Incidental Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Trial
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  18. Neural Underpinnings of Cortisol Effects on Fear Extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
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  19. Article
  20. Review

127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dominique de QuervainTransfaculty Research Platform, University of Basel, CH-4055, Basel, Switzerland.
Lars SchwabeDepartment of Cognitive Psychology, Institute of Psychology, University of Hamburg, 20146 Hamburg, Germany.
Benno RoozendaalDepartment of Cognitive Neuroscience, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucocorticoid stress hormones are crucially involved in modulating mnemonic processing of emotionally arousing experiences. They enhance the consolidation of new memories, including those that extinguish older memories, but impair the retrieval of information stored in long-term memory. As strong aversive memories lie at the core of several fear-related disorders, including post-traumatic stress disorder and phobias, the memory-modulating properties of glucocorticoids have recently become of considerable translational interest. Clinical trials have provided the first evidence that glucocorticoid-based pharmacotherapies aimed at attenuating aversive memories might be helpful in the treatment of fear-related disorders. Here, we review important advances in the understanding of how glucocorticoids mediate stress effects on memory processes, and discuss the translational potential of these new conceptual insights.

Indexed as

Stress, PsychologicalAnimalsClinical Trials as TopicExtinction, PsychologicalFearGlucocorticoidsHumansMemoryStress Disorders, Post-TraumaticGlucocorticoids

Identifiers

PMID27881856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.