ArticleScience translational medicine2016
Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition.
Article in Science translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systemic review of the role of enterotoxic Bacteroides fragilis in colorectal cancer.Neoplasia (New York, N.Y.) · 2022Pooled it
- The effect of legume supplementation on the gut microbiota in rural Malawian infants aged 6 to 12 months.The American journal of clinical nutrition · 2020Trial
- Gut microbiome in preterm infants with different weight gain outcomes.Gut microbiology · 2026Article
- Strain-level antigen variation facilitates immune evasion in Bacteroides thetaiotaomicron.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Dynamics of phage-host interactions in Bacteroides fragilis resolved by single-cell transcriptomics.Nature communications · 2026Article
- Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.Molecular nutrition & food research · 2026Review
- Identification of strain-specific cues that regulate biofilm formation inMicrobiology spectrum · 2025Article
- Oncomicrobial vaccines mitigate tumor progression via precisely targeting oncomicrobes in mice.Protein & cell · 2025Article
- Microbiome characterization of patients with Crohn disease and the use of fecal microbiota transplantation: A review.Medicine · 2025Review
- Combinatorial phenotypic landscape enables bacterial resistance to phage infection.bioRxiv : the preprint server for biology · 2025Article
- Characterization of Bacteroides fragilis from the vagina of a giant panda (Ailuropoda melanoleuca) with vaginitis.BMC veterinary research · 2024Article
- Gut microbiota in regulation of childhood bone growth.Experimental physiology · 2024Review
- Next-generation probiotics: the upcoming biotherapeutics.Molecular biology reports · 2024Review
- Multiple micronutrient deficiencies in early life cause multi-kingdom alterations in the gut microbiome and intrinsic antibiotic resistance genes in mice.Nature microbiology · 2023Article
- Inflammation: the driver of poor outcomes among children with severe acute malnutrition?Nutrition reviews · 2023Review
- From-Toilet-to-Freezer: A Review on Requirements for an Automatic Protocol to Collect and Store Human Fecal Samples for Research Purposes.Biomedicines · 2023Review
- The intersection of undernutrition, microbiome, and child development in the first years of life.Nature communications · 2023Review
- The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice.iScience · 2023Article
- 'Statistical Irreproducibility' Does Not Improve with Larger Sample Size: How to Quantify and Address Disease Data Multimodality in Human and Animal Research.Journal of personalized medicine · 2021Article
- Controlled Complexity: Optimized Systems to Study the Role of the Gut Microbiome in Host Physiology.Frontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
To model how interactions among enteropathogens and gut microbial community members contribute to undernutrition, we colonized gnotobiotic mice fed representative Bangladeshi diets with sequenced bacterial strains cultured from the fecal microbiota of two 24-month-old Bangladeshi children: one healthy and the other underweight. The undernourished donor's bacterial collection contained an enterotoxigenic Bacteroides fragilis strain (ETBF), whereas the healthy donor's bacterial collection contained two nontoxigenic strains of B. fragilis (NTBF). Analyses of mice harboring either the unmanipulated culture collections or systematically manipulated versions revealed that ETBF was causally related to weight loss in the context of its native community but not when introduced into the healthy donor's community. This phenotype was transmissible from the dams to their offspring and was associated with derangements in host energy metabolism manifested by impaired tricarboxylic acid cycle activity and decreased acyl-coenzyme A utilization. NTBF reduced ETBF's expression of its enterotoxin and mitigated the effects of ETBF on the transcriptomes of other healthy donor community members. These results illustrate how intraspecific (ETBF-NTBF) and interspecific interactions influence the effects of harboring B. fragilis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.