Evidence map›Paper›PMID 27881722›Full record

ArticleJournal of neurophysiology2017

Maintenance of neuronal size gradient in MNTB requires sound-evoked activity.

Jessica H Weatherstone, Conny Kopp-Scheinpflug, Nadia Pilati, Yuan Wang, Ian D Forsythe, Edwin W Rubel, Bruce L Tempel

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Frontiers in cellular neuroscience · 2026
    Article
  3. Article
  4. Auditory brainstem development of naked mole-rats (Proceedings. Biological sciences · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Frontiers in neuroscience · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Your genes decide what you are listening to.Channels (Austin, Tex.) · 2017
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Jessica H WeatherstoneVirginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, and Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington.
Conny Kopp-ScheinpflugDepartment of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, United Kingdom; cks@bio.lmu.de.
Nadia PilatiDepartment of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, United Kingdom.
Yuan WangVirginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, and Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington.
Ian D ForsytheDepartment of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, United Kingdom.
Edwin W RubelVirginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, and Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington.
Bruce L TempelVirginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, and Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington.
University of Washington · USUniversity of Leicester · GBFlorida State University · USLudwig-Maximilians-Universität München · DE

Funding

Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9M
Development and afferent regulation of auditory neuronsR01DC013074 · NIDCD · UNIVERSITY OF WASHINGTON · PI WANG, YUAN · 2014 to 2018
$1.9M
Medical Research Council MR/K005170/1NICHD NIH HHS U54 HD083091NIDCD NIH HHS R01 DC013074
6 · The paper itself

Abstract

The medial nucleus of the trapezoid body (MNTB) is an important source of inhibition during the computation of sound location. It transmits fast and precisely timed action potentials at high frequencies; this requires an efficient calcium clearance mechanism, in which plasma membrane calcium ATPase 2 (PMCA2) is a key component. Deafwaddler (

Indexed as

Sound2-Amino-5-phosphonovalerateAnimalsCochlear NucleusDeafnessDiphtheria ToxinEvoked Potentials, AuditoryExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsHomeodomain ProteinsMiceMice, Inbred CBAMice, TransgenicMicrotubule-Associated ProteinsMutationNeurons2-Amino-5-phosphonovalerateAtp2b2 protein, mouseDiphtheria ToxinExcitatory Amino Acid AntagonistsHomeodomain ProteinsMicrotubule-Associated ProteinsPlasma Membrane Calcium-Transporting ATPasesPou4f3 protein, mouseSodium Channel BlockersTetrodotoxinTranscription Factor Brn-3Cauditory brain stemcalyx of HeldPMCA2synaptic transmissiontonotopic gradients

Identifiers

PMID27881722
PMCPMC5304411
OpenAlexW2556820349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.