Evidence map›Paper›PMID 27881678›Full record

ArticleThe Journal of biological chemistry2017

Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3',5'-cAMP in Bacteria.

Yong Zhang, Rym Agrebi, Lauren E Bellows, Jean-François Collet, Volkhard Kaever, Angelika Gründling

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. At the Crossroad of Nucleotide Dynamics and Protein Synthesis in Bacteria.Microbiology and molecular biology reviews : MMBR · 2023
    Review
  9. Article
  10. Article
  11. RNase I regulatesThe Biochemical journal · 2018
    Article
  12. Adenylate Cyclases ofPathogens (Basel, Switzerland) · 2018
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Yong ZhangFrom the Section of Microbiology and MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom.ORCID http://orcid.org/0000-0003-2968-0081
Rym AgrebiWELBIO, Avenue Hippocrate 75, 1200 Brussels, Belgium.
Lauren E BellowsFrom the Section of Microbiology and MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom.
Jean-François ColletWELBIO, Avenue Hippocrate 75, 1200 Brussels, Belgium.
Volkhard KaeverResearch Core Unit Metabolomics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Angelika GründlingFrom the Section of Microbiology and MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom, a.grundling@imperial.ac.uk.ORCID http://orcid.org/0000-0002-6235-8687
Imperial College London · GBde Duve Institute · BEMedizinische Hochschule Hannover · DE

Funding

European Research Council 260371Medical Research Council MR/J006874/1Wellcome Trust 100289
6 · The paper itself

Abstract

The nucleotide signaling molecule 3',5'-cyclic adenosine monophosphate (3',5'-cAMP) plays important physiological roles, ranging from carbon catabolite repression in bacteria to mediating the action of hormones in higher eukaryotes, including human. However, it remains unclear whether 3',5'-cAMP is universally present in the Firmicutes group of bacteria. We hypothesized that searching for proteins that bind 3',5'-cAMP might provide new insight into this question. Accordingly, we performed a genome-wide screen and identified the essential Staphylococcus aureus tRNA m

Indexed as

Evolution, MolecularAmino Acid SequenceBinding SitesCrystallography, X-RayCyclic AMPEscherichia coliHumansKineticsMethylationModels, MolecularPhylogenyProtein ConformationS-AdenosylmethionineSequence Homology, Amino AcidStaphylococcus aureusSubstrate SpecificityCyclic AMPS-AdenosylmethioninetRNA Methyltransferasescyclic AMP (cAMP)gram-positive bacteriaprotein evolutionsignalingStaphylococcus aureus (S. aureus)

Identifiers

PMID27881678
PMCPMC5217690
OpenAlexW2553045668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.