ArticleJournal of applied physiology (Bethesda, Md. : 1985)2017
Aerobic exercise in humans mobilizes HSCs in an intensity-dependent manner.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Hematopoietic progenitor cells (HPCs) mobilization following high-intensity interval exercise in cancer patients undergoing bone marrow transplantation: preliminary results from a randomized controlled trial.Stem cell research & therapy · 2026Trial
- Examining the effect of intermittent cycling throughout a 3-h period on peripheral blood concentrations of haemopoietic stem and progenitor cells and cytolytic natural killer cells.Stem cell research & therapy · 2025Trial
- Cellular profile of hematopoietic stem cells mobilized by exercise versus G-CSF in healthy related donors.European journal of applied physiology · 2026Article
- Redefining the role of exercise: beyond medicine and polypill.EXCLI journal · 2026Article
- Intra-apheresis Cycling to Improve the Clinical Efficacy of Peripheral Blood Stem Cell Donations.Sports medicine (Auckland, N.Z.) · 2025Review
- The Effect of Exercise-Based Interventions on Health-Related Quality of Life of Patients with Hematological Malignancies: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2025Review
- The impact of acute and chronic aerobic and resistance exercise on stem cell mobilization: A review of effects in healthy and diseased individuals across different age groups.Regenerative therapy · 2024Article
- Brief cycling intervals incrementally increase the number of hematopoietic stem and progenitor cells in human peripheral blood.Frontiers in physiology · 2024Article
- Review
- The acute leukocyte and cytokine response of older adults to resistance exercise in normobaric hypoxia.Biology of sport · 2023Article
- Article
- Effect of Physical Training on Exercise-Induced Inflammation and Performance in Mice.Frontiers in cell and developmental biology · 2021Article
- Acute Exercise-Induced Oxidative Stress Does Not Affect Immediate or Delayed Precursor Cell Mobilization in Healthy Young Males.Frontiers in physiology · 2020Article
- The effects of moderate and high-intensity exercise on circulating markers of endothelial integrity and activation in young, healthy men.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Exercise and Cardiovascular Progenitor Cells.Comprehensive Physiology · 2019Review
- Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults.The Journal of physiology · 2018Article
- Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the βBrain, behavior, and immunity · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematopoietic stem and progenitor cells are necessary to maintain, repair, and reconstitute the hematopoietic blood cell system. Mobilization of these cells from bone marrow to blood can be greatly increased under certain conditions, one such being exercise. The purpose of this study was to identify the importance of exercise intensity in hematopoietic mobilization, to better understand the mobilization kinetics postexercise, and to determine if exercise is capable of mobilizing several specific populations of hematopoietic cells that have clinical relevance in a transplant setting. Healthy individuals were exercised on a cycle ergometer at 70% of their peak work rate (WR NEW & NOTEWORTHY: Here we demonstrate for the first time that mobilization of hematopoietic stem cells (HSCs) through exercise is intensity dependent, with the greatest mobilization occurring immediately after high-intensity exercise. As well, we show that exercise is a general stimulus for mobilization: increases in specific HSC populations are reliant on general mononuclear cell mobilization. Finally, we demonstrate no differences in mobilization between groups with different aerobic fitness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.