ArticleJournal of virology2017
Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production.
Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Patient-reported improvements from use of IMC-2 alone and IMC-2 and PaxlovidFrontiers in immunology · 2025Trial
- Human Sapovirus in the Post-Rotavirus Vaccine Era: From an Overlooked Gastroenteritis Pathogen to a Target for Precision Surveillance.Reviews in medical virology · 2026Review
- A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions.Heliyon · 2024Article
- Evaluating NSAIDs in SARS-CoV-2: Immunomodulatory mechanisms and future therapeutic strategies.Heliyon · 2024Review
- Review
- The roles of COX-2 in protozoan infection.Frontiers in immunology · 2023Review
- Article
- Lipid droplets and lipid mediators in viral infection and immunity.FEMS microbiology reviews · 2021Review
- Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection.Journal of virology · 2021Article
- Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication.bioRxiv : the preprint server for biology · 2020Article
- NSAIDs in patients with viral infections, including Covid-19: Victims or perpetrators?Pharmacological research · 2020Article
- Dengue Virus Induced COX-2 Signaling Is Regulated Through Nutrient Sensor GCN2.Frontiers in immunology · 2020Article
- Replication of Marek's Disease Virus Is Dependent on Synthesis ofJournal of virology · 2019Article
- Review
- Early Porcine Sapovirus Infection Disrupts Tight Junctions and Uses Occludin as a Coreceptor.Journal of virology · 2019Article
- Immune Response Modulation by Caliciviruses.Frontiers in immunology · 2019Review
- Feline calicivirus- and murine norovirus-induced COX-2/PGE2 signaling pathway has proviral effects.PloS one · 2018Article
- Prostaglandin EFrontiers in physiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
Abstract
Enteric caliciviruses in the genera Norovirus and Sapovirus are important pathogens that cause severe acute gastroenteritis in both humans and animals. Cyclooxygenases (COXs) and their final product, prostaglandin E IMPORTANCE: Sapoviruses are among the major etiological agents of acute gastroenteritis in both humans and animals, but little is known about sapovirus host factor requirements. Here, using only cultivable porcine sapovirus (PSaV) strain Cowden, we demonstrate that PSaV induced the vitalization of the cyclooxygenase (COX) and prostaglandin E
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.