Observational studyBMJ open2016
Clinical factors associated with initiation of and persistence with ADP receptor-inhibiting oral antiplatelet treatment after acute coronary syndrome: a nationwide cohort study from Finland.
Observational study in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Finnish nationwide controlled register study found increased inpatient infections in children with 22q11.2 deletion syndrome.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Short- and long-term outcomes of ST-segment elevation myocardial infarction treated with CABG: a population-based cohort study.BMJ open · 2025Article
- Value of Pharmacogenetic Testing Assessed with Real-World Drug Utilization and Genotype Data.Clinical pharmacology and therapeutics · 2025Article
- Short- and long-term mortality in patients with type 2 diabetes after myocardial infarction- a nationwide registry study.Cardiovascular diabetology · 2024Observational
- Quality of care for secondary cardiovascular disease prevention in 2009-2017: population-wide cohort study of antiplatelet therapy use in Scotland.BMJ quality & safety · 2024Article
- Ezetimibe use and mortality after myocardial infarction: A nationwide cohort study.American journal of preventive cardiology · 2024Article
- Upper gastrointestinal endoscopy procedure volume trends, perioperative mortality, and malpractice claims: Population-based analysis.Endoscopy international open · 2024Article
- Article
- Association of CHA2DS2-VASc Score with Long-Term Incidence of New-Onset Atrial Fibrillation and Ischemic Stroke after Myocardial Infarction.Journal of clinical medicine · 2022Article
- Evidence-practice gaps in P2YInternal medicine journal · 2022Article
- Poor long-term outcome in acute coronary syndrome in a real-life setting: Ten-year outcome of the TACOS study.Cardiology journal · 2021Article
- Concomitant use of drugs known to cause interactions with oral antiplatelets-polypharmacy in acute coronary syndrome outpatients in Finland.European journal of clinical pharmacology · 2020Observational
- Observational
- Usage of PCI and long-term cardiovascular risk in post-myocardial infarction patients: a nationwide registry cohort study from Finland.BMC cardiovascular disorders · 2019Observational
- Initiation And Persistence With Antiplatelet Agents Among The Patients With Acute Coronary Syndromes: A Retrospective, Observational Database Study In China.Patient preference and adherence · 2019Article
- Effects of atrial fibrillation on complications and prognosis of patients receiving emergency PCI after acute myocardial infarction.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo study patient selection for and persistence with ADP receptor-inhibiting oral antiplatelet (OAP) treatment after acute coronary syndrome (ACS).
designObservational, retrospective, cohort study linking real-life patient-level register data.
settingNationwide drug usage study using data of patients with ACS discharged from hospitals in Finland.
participantsThe study population consisted of 54 416 patients (aged ≥18 years) following hospital admission for unstable angina pectoris or myocardial infarction during 2009-2013. Patients were classified as either OAP or non-OAP users based on drug purchases within 7 days of discharge. OUTCOME MEASURES: Initiation of and a 12-month persistence with OAP medication.
resultsIn total, 49% of patients with ACS received OAP treatment after hospital discharge. Women represented 40% of the population, but only 32% of them became OAP users (adjusted OR for initiation compared with men 0.8; p<0.001). Patients not treated with percutaneous coronary intervention (PCI), elderly and patients with dementia/Alzheimer's disease, atrial fibrillation or warfarin treatment were less likely to be treated with OAP. If initiated, they were less likely to complete the recommended 12 months' medication (adjusted risk increment >38% and p<0.001 for all). The OAP users showed good compliance with immediate initiation (92% within 1 day of discharge) and high mean medication possession rate (99%). Among OAP users, the usage of other secondary prevention drugs after ACS was more common than in non-OAP-treated patients (difference >20 percentage points for each).
conclusionsOnly half of the patients with ACS received guideline-recommended ADP receptor-inhibiting OAP treatment after hospital discharge, suggesting suboptimal treatment practices. Non-PCI-treated patients and patients with increased age, unstable angina, dementia or atrial fibrillation appear to have the highest risk of deficient treatment with OAPs. OAP users, however, showed good compliance during drug usage.
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