Evidence map›Paper›PMID 27881526›Full record

ArticleBMJ open2016

Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol.

Ioana Cotlarciuc, Thomas Marjot, Muhammad S Khan, Sini Hiltunen, Elena Haapaniemi, Tiina M Metso, Jukka Putaala, Susanna M Zuurbier, Matthijs C Brouwer, Serena M Passamonti and 28 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Thrombin-Activatable Fibrinolysis Inhibitor Polymorphisms and Cerebral Venous Thrombosis in Mexican Mestizo Patients.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018
    Trial
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  14. Cerebral venous thrombosis.Nature reviews. Neurology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 12 countries.

Ioana CotlarciucInstitute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Thomas MarjotDepartment of Gastroenterology and Hepatology, University of Oxford, Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, UK.
Muhammad S KhanDepartment of Restorative Neuroscience, Imperial College London, London, UK.
Sini HiltunenDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Elena HaapaniemiDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Tiina M MetsoDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Jukka PutaalaDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Susanna M ZuurbierDepartment of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Matthijs C BrouwerDepartment of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Serena M PassamontiAngelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Paolo BucciarelliAngelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Emanuela PappalardoAngelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Tasmin PatelInstitute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Paolo CostaDepartment of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.
Marina ColombiDepartment of Molecular and Translational Medicine, Division of Biology and Genetics, University of Brescia, Brescia, Italy.
Patrícia CanhãoDepartment of Neurosciences, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal.
Aleksander TkachDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Rosa SantacroceMedical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Maurizio MargaglioneMedical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Giovanni FavuzziAtherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.
Elvira GrandoneAtherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.
Donatella ColaizzoAtherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.
Kostas SpengosDepartment of Neurology, University of Athens School of Medicine, Eginition Hospital, Athens, Greece.
Antonio ArauzStroke Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco Suarez, Mexico City, Mexico.
Amanda HodgeDepartment of Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Reina DittaDepartment of Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Stephanie DebetteDepartment of Neurology, Bordeaux University Hospital, Bordeaux University, Bordeaux, France.
Marialuisa ZeddeNeurology Unit, Stroke Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.
Guillaume PareDepartment of Pathology and Molecular Medicine, Population Health Research Institute and Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
José M FerroDepartment of Neurosciences, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal.
Vincent ThijsDepartment of Neurology, Austin Health and Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia.
Alessandro PezziniDepartment of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy.
Jennifer J MajersikDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Ida MartinelliAngelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Jonathan M CoutinhoDepartment of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Turgut TatlisumakDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Pankaj SharmaInstitute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
ISGC (International Stroke Genetics Consortium) and BEAST investigators
Helsinki University Hospital · FIFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITRoyal Holloway University of London · GBUniversity of Brescia · ITAcademic Medical Center · NLThrombosis and Atherosclerosis Research Institute · CAUniversity of Foggia · ITUniversity of Utah · USAustin Health · AUEginition Hospital · GRHospital de Santa Maria · PTImperial College London · GBInstituto Nacional de Neurología y Neurocirugía · MXMcMaster University · CAOspedale Santa Maria · ITOxford University Hospitals NHS Trust · GBUniversité de Bordeaux · FRUniversity of Amsterdam · NLUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCerebral venous thrombosis (CVT) is a rare cerebrovascular condition accounting for <1% of all stroke cases and mainly affects young adults. Its genetic aetiology is not clearly elucidated. METHODS AND ANALYSIS: To better understand the genetic basis of CVT, we have established an international biobank of CVT cases, Biorepository to Establish the Aetiology of Sinovenous Thrombosis (BEAST) which aims to recruit highly phenotyped cases initially of European descent and later from other populations. To date we have recruited 745 CVT cases from 12 research centres. As an initial step, the consortium plans to undertake a genome-wide association analysis of CVT using the Illumina Infinium HumanCoreExome BeadChip to assess the association and impact of common and low-frequency genetic variants on CVT risk by using a case-control study design. Replication will be performed to confirm putative findings. Furthermore, we aim to identify interactions of genetic variants with several environmental and comorbidity factors which will likely contribute to improve the understanding of the biological mechanisms underlying this complex disease. ETHICS AND DISSEMINATION: BEAST meets all ethical standards set by local institutional review boards for each of the participating sites. The research outcomes will be published in international peer-reviewed open-access journals with high impact and visibility. The results will be presented at national and international meetings to highlight the contributions into improving the understanding of the mechanisms underlying this uncommon but important disease. This international DNA repository will become an important resource for investigators in the field of haematological and vascular disorders.

Indexed as

Genetic Predisposition to DiseaseAdultCase-Control StudiesFactor VFemaleGenetic VariationGenome-Wide Association StudyHumansIntracranial ThrombosisMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedProthrombinRisk FactorsVenous ThrombosisYoung AdultFactor VMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanProthrombincerebral venous thrombosisischemic stroke

Identifiers

PMID27881526
PMCPMC5128947
OpenAlexW2549745012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.