ArticleJournal of the American Heart Association2016
Contemporary Trends and Age-Specific Sex Differences in Management and Outcome for Patients With ST-Segment Elevation Myocardial Infarction.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gender correlation between sleep duration and risk of coronary heart disease: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Time Course of Ischemic and Bleeding Burden in Elderly Patients With Acute Coronary Syndromes Randomized to Low-Dose Prasugrel or Clopidogrel.Journal of the American Heart Association · 2019Trial
- Persisting Sex Discrepancies in Short-Term Outcomes of Patients with ST-Segment Myocardial Infarction: Results of the ISACS-STEMI COVID-19 Registry.Journal of clinical medicine · 2026Article
- Age Differences in Acute Chest Pain Care in a Multisite US Cohort.Clinical cardiology · 2026Observational
- Clinical presentation and outcomes of acute myocardial infarction with vs. without ST elevation in octogenarians.Cardiology journal · 2026Article
- Diabetes Screening Age and the U.S. Preventive Services Task Force Guideline: Does One Size Fit All? Insights from the Middle East.Heart views : the official journal of the Gulf Heart Association · 2026Article
- A clinical nomogram for predicting major adverse cardiovascular and cerebrovascular events in elderly Chinese patients with acute coronary syndrome undergoing percutaneous coronary intervention: development and validation in a real-world cohort.Journal of geriatric cardiology : JGC · 2025Article
- The impact of uric acid on acute coronary syndrome prognosis in elderly patients.Annals of medicine · 2025Article
- Comparative effectiveness and safety of dual antiplatelet therapy with ticagrelor vs. clopidogrel in older adults with acute coronary syndrome: a target trial emulation study.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Role of physiology in the management of multivessel disease among patients with acute coronary syndrome.AsiaIntervention · 2024Review
- Antiplatelet Therapy for Elderly Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.Journal of clinical medicine · 2024Review
- Early Invasive Strategy for Octogenarians and Nonagenarians With Acute Myocardial Infarction.Circulation reports · 2024Article
- Pharmacotherapy for Coronary Artery Disease and Acute Coronary Syndrome in the Aging Population.Current atherosclerosis reports · 2024Review
- Coronary Artery Plaque Phenotype and 5-Year Clinical Outcomes in Older Patients with Non-ST Elevation Acute Coronary Syndrome.Reviews in cardiovascular medicine · 2024Article
- Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome.Open heart · 2024Article
- Clinical characteristics and long-term prognosis of female patients with acute coronary syndrome.Frontiers in cardiovascular medicine · 2024Article
- The change of inflammatory markers may predict long-term major adverse cardiovascular events in elderly patients with coronary heart disease: a retrospective cohort study.Frontiers in medicine · 2024Article
- Prognostic Impact of Percutaneous Coronary Intervention in Older Patients Hospitalized with Acute Myocardial Infarction: Real-World Findings from the Lombardy Health Database.Journal of clinical medicine · 2023Article
- Management of Coronary Artery Disease in Older Adults: Recent Advances and Gaps in Evidence.Journal of clinical medicine · 2023Review
- Clinical Profiles, Outcomes, and Sex Differences of Patients With STEMI: Findings From the NORIN-STEMI Registry.JACC. Asia · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge- and sex-specific differences exist in the treatment and outcome of ST-elevation myocardial infarction (STEMI). We sought to describe age- and sex-matched contemporary trends of in-hospital management and outcome of patients with STEMI. METHODS AND
resultsWe analyzed data from 5 Italian nationwide prospective registries, conducted between 2001 and 2014, including consecutive patients with STEMI. All the analyses were age- and sex-matched, considering 4 age classes: <55, 55 to 64, 65 to 74, and ≥75 years. A total of 13 235 patients were classified as having STEMI (72.1% men and 27.9% women). A progressive shift from thrombolysis to primary percutaneous coronary intervention occurred over time, with a concomitant increase in overall reperfusion rates (P for trend <0.0001), which was consistent across sex and age classes. The crude rates of in-hospital death were 3.2% in men and 8.4% in women (P<0.0001), with a significant increase over age classes for both sexes and a significant decrease over time for both sexes (all P for trend <0.01). On multivariable analysis, age (odds ratio 1.09, 95% CI 1.07-1.10, P<0.0001) and female sex (odds ratio 1.44, 95% CI 1.07-1.93, P=0.009) were found to be significantly associated with in-hospital mortality after adjustment for other risk factors, but no significant interaction between these 2 variables was observed (P for interaction=0.61).
conclusionsDespite a nationwide shift from thrombolytic therapy to primary percutaneous coronary intervention for STEMI affecting both sexes and all ages, women continue to experience higher in-hospital mortality than men, irrespective of age.
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