ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017
Maturity and age influence chief cell ability to transdifferentiate into metaplasia.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- The origins and progression of pyloric metaplasia following gastric mucosal injury.Physiological reviews · 2026Review
- Emerging role of spasmolytic polypeptide-expressing metaplasia in gastric cancer.Journal of gastrointestinal oncology · 2024Review
- Highlights of how single-cell analyses are illuminating differentiation and disease in the gastric corpus.American journal of physiology. Gastrointestinal and liver physiology · 2024Review
- The Importance of Th2 Immune Responses in Mediating the Progression of Gastritis-Associated Metaplasia to Gastric Cancer.Cancers · 2024Review
- The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target.Cell death discovery · 2023Review
- Role of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases.American journal of cancer research · 2023Review
- Cell plasticity in regeneration in the stomach and beyond.Current opinion in genetics & development · 2022Review
- The immune microenvironment in gastric adenocarcinoma.Nature reviews. Gastroenterology & hepatology · 2022Review
- Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa.Gut · 2022Article
- Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond.Gastroenterology · 2022Review
- ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program.EMBO reports · 2021Article
- Epithelial cell plasticity: breaking boundaries and changing landscapes.EMBO reports · 2021Review
- Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Group 2 Innate Lymphoid Cells Coordinate Damage Response in the Stomach.Gastroenterology · 2020Article
- A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle.Developmental cell · 2020Article
- The Physiology of the Gastric Parietal Cell.Physiological reviews · 2020Review
- Decrease in MiR-148a Expression During Initiation of Chief Cell Transdifferentiation.Cellular and molecular gastroenterology and hepatology · 2020Article
- Premalignant lesions and gastric cancer: Current understanding.World journal of gastrointestinal oncology · 2019Review
- Gastric Parietal Cell Physiology and Helicobacter pylori-Induced Disease.Gastroenterology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The plasticity of gastric chief cells is exemplified by their ability to transdifferentiate into spasmolytic polypeptide-expressing metaplasia (SPEM) after parietal cell loss. We sought to determine if chief cell maturity is a limiting factor in the capacity to transdifferentiate. Mist1 NEW & NOTEWORTHY: Previous investigations have indicated that spasmolytic polypeptide-expressing metaplasia (SPEM) in the stomach arises from transdifferentiation of chief cells. Nevertheless, the intrinsic properties of chief cells that influence transdifferentiation have been largely unknown. We now report that the ability to transdifferentiate into SPEM is impaired in chief cells that lack full functional maturation, and as chief cells age, they lose their ability to transdifferentiate. Thus chief cell plasticity is dependent on both cell age and maturation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.