Evidence map›Paper›PMID 27881400›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017

Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice.

Nathan C Winn, Victoria J Vieira-Potter, Michelle L Gastecki, Rebecca J Welly, Rebecca J Scroggins, Terese M Zidon, T'Keaya L Gaines, Makenzie L Woodford, Natalia G Karasseva, Jill A Kanaley and 2 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
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  9. Review
  10. Article
  11. Review
  12. Uncoupling Protein 1 Does Not Produce Heat without Activation.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Diet-Induced Thermogenesis: Principles and Pitfalls.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Nathan C WinnNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Victoria J Vieira-PotterNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.ORCID 0000-0001-7563-0806
Michelle L GasteckiNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Rebecca J WellyNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Rebecca J ScrogginsNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Terese M ZidonNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
T'Keaya L GainesNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Makenzie L WoodfordNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Natalia G KarassevaTransgenic Animal Core, University of Missouri, Columbia, Missouri.
Jill A KanaleyNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Harold S SacksEndocrine and Diabetes Division, Veterans Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
Jaume PadillaNutrition and Exercise Physiology, University of Missouri, Columbia, Missouri; padillaja@missouri.edu.
University of Missouri · USUniversity of California, Los Angeles · USUniversity of Missouri Health System · US

Funding

MINORITY BIOMEDICAL RESEARCHERS TRAINING INITIATIVER25GM056901 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI HANNINK, MARK · 1999 to 2019
$8.4M
Vascular Insulin Resistance in Obesity: Role of Endoplasmic Reticulum StressK01HL125503 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PADILLA, JAUME · 2015 to 2018
$564k
Targeting endoplasmic reticulum stress to correct vascular insulin resistance and glycemic dysregulation in diabetesR21DK105368 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI PADILLA, JAUME · 2015 to 2016
$422k
NIDDK NIH HHS R21 DK105368NIGMS NIH HHS R25 GM056901
6 · The paper itself

Abstract

We tested the hypothesis that female mice null for uncoupling protein 1 (UCP1) would have increased susceptibility to Western diet-induced "whitening" of brown adipose tissue (AT) and glucose intolerance. Six-week-old C57BL/6J wild-type (WT) and UCP1 knockout (UCP1

Indexed as

Adipose Tissue, BrownAnimalsBody WeightDiet, WesternFatty LiverFemaleGlucose IntoleranceMiceMice, Inbred C57BLMice, KnockoutObesityUncoupling Protein 1UCP1 protein, humanUncoupling Protein 1glucose intoleranceinflammationinsulin resistanceobesity

Identifiers

PMID27881400
PMCPMC5283932
OpenAlexW2552459335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.