Evidence map›Paper›PMID 27881391›Full record

ReviewThe American journal of clinical nutrition2017

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids.

Aedín Cassidy, Anne-Marie Minihane

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04160481 (A Randomised, Double-blinded, Cross-over, Placebo- Controlled Pilot Study to Investigate the Effect of Tomato Extract on TMAO in Overweight or Obese Adults), which is not on this map. Cited by 228 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04160481 nacompletednot on this mapstarted 2019, after this paper: background citation

A Randomised, Double-blinded, Cross-over, Placebo- Controlled Pilot Study to Investigate the Effect of Tomato Extract on TMAO in Overweight or Obese Adults

TypeinterventionalSponsordsm-firmenich Switzerland AGRan2019 to 2020Enrolled37ConditionsCardiovascular Risk FactorArmsFruitFlow, Placebo
3 · Its place in the literature

Who cites it

228 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  15. Dual modulation of intracellular CaJournal of molecular histology · 2026
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Flavonoids.Advances in nutrition (Bethesda, Md.) · 2026
    Article

168 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aedín CassidyDepartment of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, United Kingdom a.cassidy@uea.ac.uk.
Anne-Marie MinihaneDepartment of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.

Funding

Biotechnology and Biological Sciences Research Council BB/J004545/1
6 · The paper itself

Abstract

At a population level, there is growing evidence of the beneficial effects of dietary flavonoids on health. However, there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide interindividual variability in flavonoid absorption and metabolism. Flavonoids are extensively metabolized by phase I and phase II metabolism (which occur predominantly in the gastrointestinal tract and liver) and colonic microbial metabolism. A number of factors, including age, sex, and genotype, may affect these metabolic processes. In addition, food composition and flavonoid source are likely to affect bioavailability, and emerging data suggest a critical role for the microbiome. This review will focus on the current knowledge for the main subclasses of flavonoids, including anthocyanins, flavonols, flavan-3-ols, and flavanones, for which there is growing evidence from prospective studies of beneficial effects on health. The identification of key factors that govern metabolism and an understanding of how the differential capacity to metabolize these bioactive compounds affect health outcomes will help establish how to optimize intakes of flavonoids for health benefits and in specific subgroups. We identify research areas that need to be addressed to further understand important determinants of flavonoid bioavailability and metabolism and to advance the knowledge base that is required to move toward the development of dietary guidelines and recommendations for flavonoids and flavonoid-rich foods.

Indexed as

DietGastrointestinal MicrobiomePhenotypeAnthocyaninsFlavanonesFlavonoidsFlavonolsGastrointestinal TractGenotypeHumansLiverPlant ExtractsPlants, EdibleTreatment OutcomeAnthocyaninsFlavanonesFlavonoidsFlavonolsPlant ExtractsabsorptionADMEflavonoidsgenotypehealthmetabolismmicrobiome

Identifiers

PMID27881391
PMCPMC5183723

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.