Trial reportThe American journal of clinical nutrition2017
Changes in skeletal muscle and organ size after a weight-loss intervention in overweight and obese type 2 diabetic patients.
Trial report in The American journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Push Notifications From a Mobile App to Improve the Body Composition of Overweight or Obese Women: Randomized Controlled Trial.JMIR mHealth and uHealth · 2020Trial
- Changes in body composition with a hypocaloric diet combined with sedentary, moderate and high-intense physical activity: a randomized controlled trial.BMC women's health · 2019Trial
- Muscle movement and metabolism: exercise and skeletal muscle as mediators of health-a report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.The American journal of clinical nutrition · 2026Article
- Understanding Impact of Anti-Obesity Medications on Skeletal Muscle Mass Change Is Confounded by Measurement Methods.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Multilevel metabolic adaptation to exercise training.Communications medicine · 2026Article
- Article
- Changes in Trunk, but Not Limb, Lean Body Mass Contribute to Variability in Metabolic Adaptation Following Weight Loss.Obesity science & practice · 2025Article
- Article
- Article
- Fundamental Body Composition Principles Provide Context for Fat-Free and Skeletal Muscle Loss With GLP-1 RA Treatments.Journal of the Endocrine Society · 2024Review
- Testing a proposed mathematical model of weight loss in women enrolled on a commercial weight-loss programme: the LighterLife study.Journal of nutritional science · 2024Article
- Energy Regulation in Inflammatory Sarcopenia by the Purinergic System.International journal of molecular sciences · 2023Review
- Cross-Validation of a New General Population Resting Metabolic Rate Prediction Equation Based on Body Composition.Nutrients · 2023Article
- Tissue losses and metabolic adaptations both contribute to the reduction in resting metabolic rate following weight loss.International journal of obesity (2005) · 2022Article
- Review
- High-Protein Energy-Restriction: Effects on Body Composition, Contractile Properties, Mood, and Sleep in Active Young College Students.Frontiers in sports and active living · 2021Article
- Addressing Obesity to Promote Healthy Aging.Clinics in geriatric medicine · 2020Review
- The Relationship between Changes in Organ-Tissue Mass and Sleeping Energy Expenditure Following Weight Change in College Sumo Wrestlers.Medicina (Kaunas, Lithuania) · 2020Article
- Impact of calorie restriction on energy metabolism in humans.Experimental gerontology · 2020Review
- Resting Energy Expenditure and Organ-Tissue Body Composition 5 Years After Bariatric Surgery.Obesity surgery · 2020Article
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThe effect of a weight-loss intervention on the masses of lean tissues and organs in humans is not well known.
objectiveWe studied the effects of a diet and exercise weight-loss intervention on skeletal muscle (SM) mass and selected organs over 2 y using MRI in overweight adults with type 2 diabetes.
designParticipants were 53 women and 39 men [mean ± SD: age 58 ± 7 y; body mass index (BMI; in kg/m
resultsAdjusted for baseline weight, height, age, sex, and ethnicity, the ILI group weighed (mean ± SE) 6.6 ± 0.7 kg less after 1 y and 5.2 ± 0.7 kg less after 2 y, whereas the DSE group did not change significantly (-0.4 ± 0.6 and -1.0 ± 0.7 kg after 1 and 2 y, respectively; P-interaction < 0.001). Total SM decreased in both groups during year 1 (-1.4 ± 0.2 kg; P < 0.001) with appendicular SM regained during year 2. Liver and spleen masses decreased in the ILI group (-0.12 ± 0.02 and -0.006 ± 0.003 kg, respectively) but were unchanged in the DSE group (0.00 ± 0.02 and 0.004 ± 0.003 kg, respectively). Kidney mass decreased by 0.013 ± 0.003 kg (P < 0.001) over 2 y in both groups.
conclusionsDecreases in liver (in Caucasians but not African Americans) and spleen were detected after a 6.2-kg weight reduction compared with a control group. SM and kidney mass decreased in both groups. Appendicular SM was regained during the second year whereas trunk SM was not. No evidence of a disproportionate loss of high-metabolic rate organs (heart, liver, kidney, spleen) compared with SM was found.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.