ArticleJournal of orthopaedic surgery and research2016
Polypharmacy and adverse outcomes after hip fracture surgery.
Article in Journal of orthopaedic surgery and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Beneficial outcomes of medication review in patients with hip fractures: a systematic review.European geriatric medicine · 2025Pooled it
- Preoperative Deprescribing for Medical Optimization of Older Adults Undergoing Surgery: A Systematic Review.Journal of the American Medical Directors Association · 2022Pooled it
- Association of polypharmacy and perioperative outcomes: Systematic review and meta-analysis.Journal of perioperative practicePooled it
- Real-world evidence of the impact of polypharmacy on mortality and recovery after hip fracture in elderly patients.Scientific reports · 2026Observational
- Article
- Outcome analysis after cephalomedullary nail implantation in older adults and elderly patients with per-, sub- or intertrochanteric femur fractures.BMC research notes · 2025Article
- One-Year Survival and Postoperative Complications in Older Patients with Intertrochanteric Fractures: Association with Polypharmacy-A Multicenter Retrospective Cohort Study.Drugs & aging · 2025Article
- Evaluation of drug prescriptions on hospital admission in older trauma patients using the Fit fOR The Aged (FORTA) rules.Zeitschrift fur Gerontologie und Geriatrie · 2024Observational
- Association of postoperative opioid type with mortality and readmission rates: multicentre retrospective cohort study.BJS open · 2024Article
- Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up.Scientific reports · 2024Article
- Emergency department visits and hospital readmissions after a deprescribing intervention among hospitalized older adults.Journal of the American Geriatrics Society · 2024Article
- Article
- Orthogeriatric Assessment of the Elderly Patient with Fragility Hip Fracture: Preliminary Results of a Prospective Study.Journal of personalized medicine · 2023Article
- Clinical pharmacist intervention to improve medication safety for hip fracture patients through secondary and primary care settings: a nonrandomised controlled trial.Journal of orthopaedic surgery and research · 2023Article
- Article
- Review
- The prevalence of polypharmacy and fall-risk-increasing drugs after hospital discharge for hip fracture: A retrospective study.Journal of frailty, sarcopenia and falls · 2022Article
- Recommendations made by patients, caregivers, providers, and decision-makers to improve transitions in care for older adults with hip fracture: a qualitative study in Ontario, Canada.BMC geriatrics · 2022Article
- Survival Impact of Long-Term Tramadol Use on Breast Cancer for Patients with Chronic Pain: A Propensity Score-Matched Population-Based Cohort Study.Journal of personalized medicine · 2022Article
- Effect of Perioperative Opioid Use on Patients Undergoing Hip Arthroscopy.Orthopaedic journal of sports medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to explore the effects of polypharmacy and specific drug classes on readmissions and mortality after hip surgery.
methodsWe analyzed data on 272 consecutive hip fracture patients (72.1% females; age 82 ± 9 years) who underwent acute hip replacement. We collected detailed data on the pharmacological treatment upon admission and discharge. Patients were followed up over a period of 6 months after discharge using the Swedish National Hospital Discharge Register and the Swedish National Cause of Death Register.
resultsAfter 6 months, 86 patients (31.6%) were readmitted, while 36 patients (13.2%) died. The total number of medications upon discharge was predictive of rehospitalization (odds ratio (OR) 1.08, 95%CI 1.01-1.17, p = 0.030) but not predictive of mortality. The use of antiosteoporotic agents (OR 1.86, 95%CI 1.06-3.26, p = 0.03), SSRIs (OR 1.90, 95%CI 1.06-3.42, p = 0.03), and eye drops (OR 4.12, 95%CI 1.89-8.97, p = 0.0004) were predictive of rehospitalization. Treatment with vitamin K antagonists (OR 4.29, 95%CI 1.19-15.39, p = 0.026), thiazides (OR 4.10, 95%CI 1.30-12.91, p = 0.016), and tramadol (OR 2.84, 95%CI 1.17-6.90, p = 0.021) predicted readmissions due to a new fall/trauma.
conclusionsThe total number of medications, use of antiosteoporotic agents, SSRIs, and eye drops predicted rehospitalization after hip fracture surgery, while use of vitamin K antagonists, thiazides, and tramadol was associated with readmissions due to a traumatic fall.
trial registrationHip fractures and polypharmacy in the elderly. Stimulus Project for the Elderly 2009-2011 (Reg no 2009-11-26). Swedish National Board of Health and Welfare.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.