Evidence map›Paper›PMID 27881119›Full record

ArticleBMC complementary and alternative medicine2016

Antibacterial and antifungal potentials of the solvents extracts from Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum.

Abdul Sadiq, Sadiq Ahmad, Rahmat Ali, Fawad Ahmad, Sajjad Ahmad, Anwar Zeb, Muhammad Ayaz, Farhat Ullah, Abu Nasar Siddique

Open access · goldAbstract read
In one paragraph

Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Abdul SadiqDepartment of Pharmacy, University of Malakand, Chakdara, 18000, Dir (L), KPK, Pakistan. sadiquom@yahoo.com.
Sadiq AhmadDepartment of Pharmacy, University of Malakand, Chakdara, 18000, Dir (L), KPK, Pakistan.
Rahmat AliDepartment of Pharmacy, University of Malakand, Chakdara, 18000, Dir (L), KPK, Pakistan.
Fawad AhmadDepartment of Pharmacy, University of Malakand, Chakdara, 18000, Dir (L), KPK, Pakistan.
Sajjad AhmadDepartment of Pharmacy, University of Malakand, Chakdara, 18000, Dir (L), KPK, Pakistan.
Anwar ZebDepartment of Pharmacy, University of Malakand, Chakdara, 18000, Dir (L), KPK, Pakistan.
Muhammad AyazDepartment of Pharmacy, University of Malakand, Chakdara, 18000, Dir (L), KPK, Pakistan.
Farhat UllahDepartment of Pharmacy, University of Malakand, Chakdara, 18000, Dir (L), KPK, Pakistan.
Abu Nasar SiddiqueDepartment of Biotechnology, Bacha Khan University, Charsadda, 24420, KPK, Pakistan.
University of Malakand · PKBacha Khan University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHerbal medicines have long been used for various ailments in various societies and natural bioactive compounds are gaining more and more importance due to various factors. In this context, three plant species i.e., Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum have been aimed for the scientific verification of their purported traditional uses against various infectious diseases.

methodsIn this study, three plants were assayed for antibacterial and antifungal potentials. The antibacterial investigations were performed via well diffusion method and nutrient broth dilution method. The bacterial strains used in the study were Enterococcus faecalis, Proteus mirabilis, Escherichia coli, Salmonella typhi, Klebsiella pneumonia and Pseudomonas aeruginosa. The antifungal potential was investigated by dilution method of Muller-Hinton agar media of the plants' samples. The fungal strains used were Aspergillis fumigatus, Aspergillis flavus and Aspergillis niger. Ceftriaxone and nystatin were used as standard drugs in antibacterial and antifungal assays respectively.

resultsDifferent fractions from N. thomsonianum were tested against five bacterial strains while the samples from A. consanguineum and E. caeruleum were tested against six bacterial strains. All the samples exhibited prominent antibacterial activity against the tested strains. Overall, chloroform and ethyl acetate fractions were found most potent among the three plants' samples. N. thomsonianum excelled among the three plants in antibacterial activity. Similarly, in antifungal assay, N. thomsonianum exhibited strong antifungal activity against the fungal strains. The chloroform fraction displayed MFCs of 175.67 ± 5.20***, 29.33 ± 5.48*** and 63.00 ± 4.93*** μg/ml against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger respectively. The whole study demonstrates that all the three plant species were active against tested bacterial and fungal strains.

conclusionIt can be concluded from our findings that N. thomsonianum, A. consanguineum and E. caeruleum have broad antibacterial and antifungal potentials. In all of the plants' samples, chloroform and ethyl acetate fractions were more active. Furthermore, being the potent samples, the chloroform and ethyl acetate fractions of these plants can be subjected to column chromatography for the isolation of more effective antimicrobial drugs.

Indexed as

AlliumAnti-Bacterial AgentsAntifungal AgentsEryngiumLiliaceaeMicrobial Sensitivity TestsPakistanPlant ExtractsPlants, MedicinalSolventsAnti-Bacterial AgentsAntifungal AgentsPlant ExtractsSolventsAllium consanguineumAntibacterialAntifungalEryngium caeruleumMFCMICNotholirion thomsonianumZOI

Identifiers

PMID27881119
PMCPMC5122145
OpenAlexW2553138855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.