Evidence map›Paper›PMID 27881099›Full record

Trial reportBMC infectious diseases2016

Predictors of HIV infection: a prospective HIV screening study in a Ugandan refugee settlement.

Kelli N O'Laughlin, Dustin J Rabideau, Julius Kasozi, Robert A Parker, Nirma D Bustamante, Zikama M Faustin, Kelsy E Greenwald, Rochelle P Walensky, Ingrid V Bassett

Registry-linked trialOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06270160 (Tushirikiane-4-Uthabiti), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06270160 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Tushirikiane-4-Uthabiti (Supporting Each Other For Resilience)

TypeinterventionalSponsorUniversity of TorontoRan2024 to 2024Enrolled432ConditionsFinancial Stress, Social Functioning, Social SkillsArmsHIVST, mHealth, Creating Futures Livelihoods program
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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  9. Factors Associated with Sexually Transmitted Infections among Users of Voluntary HIV Counseling and Testing Centers in Portugal.International journal of sexual health : official journal of the World Association for Sexual Health · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Kelli N O'LaughlinDepartment of Emergency Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. kolaughlin@partners.org.
Dustin J RabideauMGH Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA.
Julius KasoziUnited Nations High Commissioner for Refugees, Representation in Uganda, PO Box 3813, Kampala, Uganda.
Robert A ParkerMedical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA, 02114-2698, USA.
Nirma D BustamanteDepartment of Emergency Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Zikama M FaustinBugema University, Kasese Campus, PO Box 6529, Kampala, Uganda.
Kelsy E GreenwaldHarvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Rochelle P WalenskyMedical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA, 02114-2698, USA.
Ingrid V BassettMedical Practice Evaluation Center, Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA, 02114-2698, USA.
Harvard University · USJohns Hopkins University Center for AIDS ResearchBugema University · UGDana-Farber/Harvard Cancer Center · USLemuel Shattuck Hospital · USMassachusetts General Hospital · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Optimizing HIV Care in Less Developed CountriesR01AI058736 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Emily Parker Hyle · 2004 to 2026
$21.5M
Linkage & Retention: A Randomized Trial to Optimize HIV/TB Care in South AfricaR01MH090326 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BASSETT, INGRID VALERIE · 2010 to 2014
$2.9M
Linking Refugees to HIV Clinical Care in UgandaK23MH108440 · NIMH · UNIVERSITY OF WASHINGTON · PI O'LAUGHLIN, KELLI NICOLE · 2016 to 2020
$990k
NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI058736NIMH NIH HHS K23 MH108440NIMH NIH HHS R01 MH090326
6 · The paper itself

Abstract

backgroundThe instability faced by refugees may place them at increased risk of exposure to HIV infection. Nakivale Refugee Settlement in southwestern Uganda hosts 68,000 refugees from 11 countries, many with high HIV prevalence. We implemented an HIV screening program in Nakivale and examined factors associated with new HIV diagnosis.

methodsFrom March 2013-November 2014, we offered free HIV screening to all clients in the Nakivale Health Center while they waited for their outpatient clinic visit. Clients included refugees and Ugandan nationals accessing services in the settlement. Prior to receiving the HIV test result, participants were surveyed to obtain demographic information including gender, marital status, travel time to reach clinic, refugee status, and history of prior HIV testing. We compared variables for HIV-infected and non-infected clients using Pearson's chi-square test, and used multivariable binomial regression models to identify predictors of HIV infection.

resultsDuring the HIV screening intervention period, 330 (4%) of 7766 individuals tested were identified as HIV-infected. Refugees were one quarter as likely as Ugandan nationals to be HIV-infected (aRR 0.27 [0.21, 0.34], p < 0.0001). Additionally, being female (aRR 1.43 [1.14, 1.80], p = 0.002) and traveling more than 1 h to the clinic (aRR 1.39 [1.11, 1.74], p = 0.003) increased the likelihood of being HIV-infected. Compared to individuals who were married or in a stable relationship, being divorced/separated/widowed increased the risk of being HIV-infected (aRR 2.41 [1.88, 3.08], p < 0.0001), while being single reduced the risk (aRR 0.60 [0.41, 0.86], p < 0.0001). Having been previously tested for HIV (aRR 0.59 [0.47, 0.74], p < 0.0001) also lowered the likelihood of being HIV-infected.

conclusionsIn an HIV screening program in a refugee settlement in Uganda, Ugandan nationals are at higher risk of having HIV than refugees. The high HIV prevalence among clients seeking outpatient care, including Ugandan nationals and refugees, warrants enhanced HIV screening services in Nakivale and in the surrounding region. Findings from this research may be relevant for other refugee settlements in Sub-Saharan Africa hosting populations with similar demographics, including the 9 other refugee settlements in Uganda.

Indexed as

Mass ScreeningRefugeesAdolescentAdultAgedAged, 80 and overFemaleHIV InfectionsHumansMaleMiddle AgedPrevalenceProspective StudiesRegression AnalysisRisk FactorsUgandaHIVHIV screeningHIV testingRefugeesub-Saharan Africa

Identifiers

PMID27881099
PMCPMC5120554
OpenAlexW2551395989

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.