Evidence map›Paper›PMID 27880974›Full record

ArticleClinical and experimental immunology2017

Deep sequencing of the TCR-β repertoire of human forkhead box protein 3 (FoxP3)

A Golding, S Darko, W H Wylie, D C Douek, E M Shevach

Abstract read
In one paragraph

Article in Clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Human TCR repertoire in cancer.Cancer medicine · 2024
    Review
  2. Review
  3. Review
  4. Article
  5. Circulating gluten-specific, but not CMV-specific, CD39Clinical & translational immunology · 2020
    Article
  6. Article
  7. The Role of the Thymus in the Immune Response.Thoracic surgery clinics · 2019
    Review
  8. Tumor-infiltrating human CD4Science immunology · 2019
    Article
  9. Review
  10. Abnormalities of T-cell receptor repertoire in CD4The Journal of allergy and clinical immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A GoldingLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3659-6654
S DarkoVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
W H WylieVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
D C DouekVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
E M ShevachLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Funding

Studies of Human T Regulatory CellsZIAAI001046 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SHEVACH, ETHAN · 2009 to 2025
$10.5M
Investigation of Regulatory T Cells in Veterans with Rheumatologic DiseaseIK2CX000649 · VA · BALTIMORE VA MEDICAL CENTER · PI GOLDING, AMIT · 2012 to 2015
–
CSRD VA IK2 CX000649
6 · The paper itself

Abstract

Maintenance of peripheral tolerance requires a balance between autoreactive conventional T cells (T

Indexed as

High-Throughput Nucleotide SequencingPhenotypeBiomarkersClonal EvolutionComplementarity Determining RegionsForkhead Transcription FactorsHumansImmunophenotypingReceptors, Antigen, T-Cell, alpha-betaT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsVDJ ExonsBiomarkersComplementarity Determining RegionsForkhead Transcription FactorsFOXP3 protein, humanReceptors, Antigen, T-Cell, alpha-betadeep sequencingregulatory T cellsT cells repertoire

Identifiers

PMID27880974
PMCPMC5343369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.