ArticleCell reports2016
Blunted mGluR Activation Disinhibits Striatopallidal Transmission in Parkinsonian Mice.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- Distinct modes of dopamine modulation on striatopallidal synaptic transmission.Nature communications · 2026Article
- Chronic Administration of Atomoxetine and Methylphenidate Induces Differential Alterations in the Hippocampus and Striatum of Young Rats.Neurotoxicity research · 2026Article
- Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases-an update.Acta pharmacologica Sinica · 2025Review
- Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice.Glia · 2025Article
- Article
- Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors.bioRxiv : the preprint server for biology · 2025Article
- Sonic Hedgehog Mediates High Frequency-Dependent Deep Brain Stimulation for the Correction of Motor Deficits in a Parkinson's Disease Model.Neuroscience bulletin · 2024Article
- Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus.Current neuropharmacology · 2024Article
- Optoα1AR activation in astrocytes modulates basal hippocampal synaptic excitation and inhibition in a stimulation-specific manner.Hippocampus · 2023Article
- Cell and circuit complexity of the external globus pallidus.Nature neuroscience · 2023Review
- Astrocyte activities in the external globus pallidus regulate action-selection strategies in reward-seeking behaviors.Science advances · 2023Article
- Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons.Nature neuroscience · 2022Article
- Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia.Molecular psychiatry · 2022Article
- Article
- Characterization of the GfaABC1D promoter to selectively target astrocytes in the rhesus macaque brain.Journal of neuroscience methods · 2022Article
- Astrocyte-neuron interaction in the dorsal striatum-pallidal circuits and alcohol-seeking behaviors.Neuropharmacology · 2021Review
- Striatal Direct Pathway Targets Npas1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The prevailing circuit model predicts that hyperactivity of the striatopallidal pathway and subsequently increased inhibition of external globus pallidus (GPe) neurons lead to the hypokinetic symptoms of Parkinson's disease (PD). It is believed that hyperactivity of the striatopallidal pathway is due to inactivity of dopamine receptors on the somatodendritic membrane of striatopallidal neurons, but the exact cellular underpinnings remain unclear. In this study, we show that mouse GPe astrocytes critically control ambient glutamate level, which in turn gates striatopallidal transmission via the activation of presynaptic metabotropic glutamate receptors. This presynaptic inhibition of striatopallidal transmission is diminished after the chronic loss of dopamine. Elevation of intracellular glutamate content in astrocytes restores the proper regulation of the striatopallidal input in PD models. These findings argue that astrocytes are key regulators of the striatopallidal synapse. Targeting this cell class may serve as an alternative therapeutic strategy for PD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.