Evidence map›Paper›PMID 27880898›Full record

ArticleCell reports2016

HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C

Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

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  15. Contribution of proteasome-catalyzed peptideProceedings of the National Academy of Sciences of the United States of America · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Zhansong LinCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Kimiko KurokiLaboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan.
Nozomi KuseCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Xiaoming SunCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Tomohiro AkahoshiCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Ying QiCancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD 21701, USA.
Takayuki ChikataCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Takuya NarutoCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Madoka KoyanagiCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Hayato MurakoshiCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan.
Hiroyuki GatanagaCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan; AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.
Shinichi OkaCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan; AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 162-8655, Japan.
Mary CarringtonCancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratories for Cancer Research, Frederick, MD 21701, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139-3583, USA.
Katsumi MaenakaLaboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan.
Masafumi TakiguchiCenter for AIDS Research, Kumamoto University, Chuo-ku, Kumamoto 860-0811, Japan. Electronic address: masafumi@kumamoto-u.ac.jp.
Kumamoto University · JPHokkaido University · JPNational Center for Global Health and Medicine · JPLeidos Biomedical Research Inc. (United States)Ragon Institute of MGH, MIT and Harvard · US

Funding

Effects of genetic polymorphism in MHC, KIR, and related loci on human diseaseZIABC010791 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2009 to 2025
$18.2M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Natural killer (NK) cells control viral infection in part through the interaction between killer cell immunoglobulin-like receptors (KIRs) and their human leukocyte antigen (HLA) ligands. We investigated 504 anti-retroviral (ART)-free Japanese patients chronically infected with HIV-1 and identified two KIR/HLA combinations, KIR2DL2/HLA-C

Indexed as

AllelesAsian PeopleChronic DiseaseHIV-1HIV InfectionsHLA-C AntigensHumansKiller Cells, NaturalReceptors, KIR2DL2Viral LoadVirus ReplicationHLA-C AntigensKIR2DL2 protein, humanReceptors, KIR2DL2HIV-1HLA-CKIR2DL2NK cells

Identifiers

PMID27880898
PMCPMC5184766
OpenAlexW2549864731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.